Optoacoustic diagnostic modality: from idea to clinical studies with highly compact laser diode-based systems.
Optoacoustic diagnostic modality: from idea to clinical studies with highly compact laser diode-based systems.
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DOI：
10.1117/1.jbo.22.9.091512
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发表时间：
2017-09-01
影响因子：
3.5
通讯作者：
Esenaliev RO
中科院分区：
文献类型：
--
作者：
Esenaliev RO
光声（光声）诊断模式是一种结合了高光学对比度和超声空间分辨率的技术。我们提出了使用光声技术的应用，包括癌症检测，监测热疗（高温，凝固和冷冻），监测脑血氧合的创伤性脑损伤患者，新生儿患者，胎儿在晚期分娩，中心静脉氧合监测，总血红蛋白浓度监测以及血肿检测和表征。我们开发并建造了基于光学参量解调器的系统和多波长、光纤耦合、高度紧凑、基于激光二极管的系统，用于光声成像、监测和传感。为了提供足够的输出脉冲能量，建立了一个专门设计的光纤系统，并纳入超灵敏，宽带光声探头。我们对系统和光声探头进行了临床前和临床测试，大多数应用采用后向模式，乳腺癌和脑应用采用前向模式。高脉冲能量和重复率允许从脑血管（例如上级矢状窦、中央静脉、外周静脉和动脉）以及颅内血肿快速采集具有高信噪比的数据。光声系统能够自动、实时、连续地测量这些血管中的血氧。
Optoacoustic (photoacoustic) diagnostic modality is a technique that combines high optical contrast and ultrasound spatial resolution. We proposed using the optoacoustic technique for a number of applications, including cancer detection, monitoring of thermotherapy (hyperthermia, coagulation, and freezing), monitoring of cerebral blood oxygenation in patients with traumatic brain injury, neonatal patients, fetuses during late-stage labor, central venous oxygenation monitoring, and total hemoglobin concentration monitoring as well as hematoma detection and characterization. We developed and built optical parametric oscillator-based systems and multiwavelength, fiber-coupled highly compact, laser diode-based systems for optoacoustic imaging, monitoring, and sensing. To provide sufficient output pulse energy, a specially designed fiber-optic system was built and incorporated in ultrasensitive, wideband optoacoustic probes. We performed preclinical and clinical tests of the systems and the optoacoustic probes in backward mode for most of the applications and in forward mode for the breast cancer and cerebral applications. The high pulse energy and repetition rate allowed for rapid data acquisition with high signal-to-noise ratio from cerebral blood vessels, such as the superior sagittal sinus, central veins, and peripheral veins and arteries, as well as from intracranial hematomas. The optoacoustic systems were capable of automatic, real-time, continuous measurements of blood oxygenation in these blood vessels.