Gliomas and the vascular fragility of the blood brain barrier.
Gliomas and the vascular fragility of the blood brain barrier.
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DOI：
10.3389/fncel.2014.00418
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发表时间：
2014
影响因子：
5.3
通讯作者：
Moura-Neto V
中科院分区：
文献类型：
--
作者：
Dubois LG;Campanati L;Righy C;D'Andrea-Meira I;Spohr TC;Porto-Carreiro I;Pereira CM;Balça-Silva J;Kahn SA;DosSantos MF;Oliveira Mde A;Ximenes-da-Silva A;Lopes MC;Faveret E;Gasparetto EL;Moura-Neto V
星形胶质细胞是神经胶质细胞家族的成员，通过可溶性因子的交换或通过直接接触神经元和其他脑细胞（如小胶质细胞和内皮细胞）而相互作用。星形胶质细胞投射与血管相互作用，并作为血脑屏障（BBB）的附加元件。由于机制尚未完全了解，星形胶质细胞可以发生致癌转化并产生胶质瘤。肿瘤利用BBB来确保存活和持续生长。胶质瘤可以发展成非常侵袭性的肿瘤，胶质母细胞瘤（GBM），其特征在于高度异质的细胞群体（包括肿瘤干细胞）、广泛的增殖和迁移。然而，神经胶质瘤也可以引起缓慢生长的肿瘤，在这两种情况下，血液通过BBB的流入是至关重要的。神经胶质瘤细胞在血管延伸的引导下迁移到大脑的不同区域，在健康的邻近组织中定居。在临床背景下，GBM可导致肿瘤源性癫痫发作，这对患者和临床医生来说是一个挑战，因为用于其治疗的药物必须能够穿过BBB。不受控制的快速生长还导致肿瘤块中嵌合和脆弱血管的破坏，从而导致瘤周水肿。虽然激素疗法目前用于控制水肿，但它并不总是有效的。在这篇综述中，我们评论了上面提到的几点，考虑到血脑屏障的重要性以及当这一屏障受到影响时所引起的担忧。
Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the BBB and the concerns that arise when this barrier is affected.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
影响因子：
3.3
作者：
da Fonseca, A. C. C.;Romao, L.;Lima, F. R. S.
通讯作者：
Lima, F. R. S.
影响因子：
4.4
作者：
Claassen, J;Hirsch, LJ;Mayer, SA
通讯作者：
Mayer, SA
影响因子：
14.5
作者：
Chirasani, Sridhar Reddy;Sternjak, Alexander;Glass, Rainer
通讯作者：
Glass, Rainer
影响因子：
4.1
作者：
Chang, Edward F.;Potts, Matthew B.;Berger, Mitchel S.
通讯作者：
Berger, Mitchel S.