The use of tumor growth kinetics in planning "curative" chemotherapy of advanced solid tumors.
The use of tumor growth kinetics in planning "curative" chemotherapy of advanced solid tumors.
复制标题
利用肿瘤生长动力学规划晚期实体瘤的“治愈性”化疗。
作者：
F. Schabel
总结数据（包括先前发表的和新的）表明，随着动物肿瘤大小的增加，处于细胞分裂周期的活肿瘤细胞的生长分数（GF）降低。随着GF降低，对抗代谢药物的敏感性降低。大量（>108）存活肿瘤细胞群的显著减少之后是GF增加和对抗代谢药物的敏感性增加。基于这些概念，治疗恶性疾病的合理化疗方法涉及用高反应性和细胞周期非特异性剂（例如，烷化剂），然后是细胞周期特异性抗癌剂（例如，抗代谢物）。
Summary Data are presented (both previously published and new) which suggest that, as tumors of animals increase in size, the growth fraction (GF) of the viable tumor cells that are in the cell division cycle decreases. As the GF decreases, sensitivity to antimetabolite drugs decreases. Significant reduction of a large (>108) viable tumor cell population is followed by an increase in GF and increased sensitivity to antimetabolite drugs. Based on these concepts, a rational chemotherapeutic approach to treatment of malignant disease involving sequential therapy with highly reactive and cell cycle-nonspecific agents (e.g., alkylating agents) followed by cell cycle-specific anticancer agents (e.g., antimetabolites) is suggested.