Plants as a source of anti-cancer and anti-HIV agents
Plants as a source of anti-cancer and anti-HIV agents
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DOI：
10.1111/j.1744-7348.2003.tb00278.x
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发表时间：
2003-01-01
影响因子：
2.6
通讯作者：
Newman, DJ
中科院分区：
文献类型：
--
作者：
Cragg, GM;Newman, DJ
植物衍生化合物在几种临床有用的抗癌药物的开发中发挥了重要作用。这些药物包括长春花碱、长春新碱、喜树碱衍生物、拓扑替康和伊立替康、依托泊苷和紫杉醇(紫杉醇(注册商标))。几种有希望的新药物正在临床开发中，这些药物基于对癌症相关分子靶点的选择性活性，包括黄烷醇和康贝沙丁A4磷酸。最近，植物已经产生了几种显示出抗艾滋病活性的药物，其中一种是(+)-Calanolide A，正在进行临床开发。
Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, and paclitaxel (Taxol(R)). Several promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and Combretastatin A4 phosphate. Recently, plants have yielded several agents showing anti-AIDS activity, and one of these, (+)-calanolide A, is in clinical development.