Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
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DOI：
10.1001/jama.292.8.927
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发表时间：
2004-08-25
影响因子：
120.7
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Schulze, MB;Manson, JE;Hu, FB
含糖饮料，如软饮料和水果饮料含有大量易吸收的糖，可能会导致体重增加，并增加患2型糖尿病的风险，但这些关系在成年人中得到的解决最少。目的探讨含糖饮料与女性体重变化及2型糖尿病发病风险的关系。设计、环境和参与者在1991 - 1999年护士健康研究II中对妇女进行了前瞻性队列分析。糖尿病分析包括1991年基线时无糖尿病和其他主要慢性病的91249名妇女。体重变化分析包括51603名女性，她们在1991年、1995年和1999年获得了完整的饮食信息和体重。在716300人年的随访中，我们确定了741例确诊的2型糖尿病病例。主要观察指标：体重增加和2型糖尿病发病率。结果那些稳定的消费模式在体重增加没有区别,但在四年期间体重增加是最高的女性增加了含糖软饮料消费从1或更少的饮料每天每周1或更多的饮料(multivariate-adjusted意味着,4.69公斤1991年至1995年和1995年到1999年4.20公斤),最小的女性减少摄入量(1.34和0.15千克2期,分别)在调整了生活方式和饮食混杂因素后。与少喝果汁饮料相比，多喝果汁饮料也会导致体重增加。在对潜在混杂因素进行调整后，每天饮用1杯或更多含糖软饮料的女性患2型糖尿病的相对风险[RR]为1.83(95%可信区间[CI]， 1.42-2.36
Context Sugar-sweetened beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain and an increased risk of type 2 diabetes, but these relationships have been minimally addressed in adults.Objective To examine the association between consumption of sugar-sweetened beverages and weight change and risk of type 2 diabetes in women.Design, Setting, and Participants Prospective cohort analyses conducted from 1991 to 1999 among women in the Nurses' Health Study II. The diabetes analysis included 91249 women free of diabetes and other major chronic diseases at baseline in 1991. The weight change analysis included 51603 women for whom complete dietary information and body weight were ascertained in 1991, 1995, and 1999. We identified 741 incident cases of confirmed type 2 diabetes during 716300 person-years of follow-up.Main Outcome Measures Weight gain and incidence of type 2 diabetes.Results Those with stable consumption patterns had no difference in weight gain, but weight gain over a 4-year period was highest among women who increased their sugar-sweetened soft drink consumption from 1 or fewer drinks per week to 1 or more drinks per day (multivariate-adjusted means, 4.69 kg for 1991 to 1995 and 4.20 kg for 1995 to 1999) and was smallest among women who decreased their intake (1.34 and 0.15 kg for the 2 periods, respectively) after adjusting for lifestyle and dietary confounders. increased consumption of fruit punch was also associated with greater weight gain compared with decreased consumption. After adjustment for potential confounders, women consuming 1 or more sugar-sweetened soft drinks per day had a relative risk [RR] of type 2 diabetes of 1.83 (95% confidence interval [CI], 1.42-2.36; P