Th1/Th2 polarization in tonsillar lymphocyte form patients with IgA nephropathy
Th1/Th2 polarization in tonsillar lymphocyte form patients with IgA nephropathy
复制标题
IgA肾病患者扁桃体淋巴细胞Th1/Th2极化
DOI：
10.3109/0886022x.2013.862809
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发表时间：
2014-04-01
期刊：
影响因子：
3
通讯作者：
Liu, Fuyou
中科院分区：
文献类型：
--
作者：
He, Liyu;Peng, Youming;Liu, Fuyou
Th 1/Th 2细胞因子失衡在伊加肾病（IgAN）的发生、发展中起重要作用。IgAN的临床发展和恶化通常在上呼吸道感染发作之前发生，并且腭扁桃体代表上呼吸道的主要免疫活性组织。本研究检测了22例扁桃体炎IgAN患者的扁桃体淋巴细胞，并以24例慢性扁桃体炎但无肾脏疾病患者的扁桃体作为对照。我们发现IgAN患者扁桃体中存在向Th 2反应的两极分化。在接触致敏过程中以及通过佐剂如诱导T辅助细胞1型（Th 1）应答的脂多糖（LPS）或诱导T辅助细胞2型（Th 2）应答的α-溶血性链球菌（HS），TH 0细胞被差异性地动员。IgAN组Th 1/Th 2比值与蛋白尿及肾脏病理改变相关。我们的研究表明IgAN与Th 1/Th 2平衡的变化有关，有利于Th 2淋巴细胞。
Abstract Imbalance of Th1/Th2 pro-inflammatory cytokines plays an important role in the development and progression of IgA nephropathy (IgAN). Clinical development and exacerbation of IgAN are frequently preceded by episodes of upper respiratory tract infection, and palatine tonsils represent the predominant immunocompetent tissue of the upper respiratory tract. This study examined tonsillar lymphocytes of IgAN who suffered from tonsillitis (n = 22), and using tonsils derived from patients with chronic tonsillitis (n = 24) but without renal disease as a control. We identified a polarization toward Th2 response in tonsils of IgAN patients. TH0 cells are differentially mobilized during contact sensitization and by adjuvants such as lipopolysaccharide (LPS) that induce T-helper type 1 (Th1) responses, or α-hemolytic streptococcus (HS) that induces T-helper type 2 (Th2) responses. Th1:Th2 ratio is correlated with proteinuria and renal pathologic changes in IgAN group. Our study suggests that IgAN is associated with the change in Th1/Th2 balance in favor of Th2 lymphocytes.