Nuclear factor-KB: a friend or a foe in cancer?
Nuclear factor-KB: a friend or a foe in cancer?
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DOI：
10.1016/j.bcp.2004.04.026
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发表时间：
2004-09-15
影响因子：
5.8
通讯作者：
Aggarwal, BB
中科院分区：
文献类型：
--
作者：
Shishodia, S;Aggarwal, BB
核转录因子NF-κ B，最初是作为一种在B细胞核中与免疫球蛋白κ轻链增强子结合的因子被发现的，此后被证明在所有细胞类型的细胞质中普遍表达，从果蝇到人都是保守的。它只有在激活时才转移到细胞核，在那里它调节200多个基因的表达，这些基因控制免疫系统，生长，和炎症。NF-κ B的失调可以介导包括癌症在内的多种疾病。NF-kappaB激活对癌症是有益还是有害是有争议的。开发靶向NF-κ B的新疗法需要充分了解其在病理学和生理学中的作用。目前的审查是试图描述NF-κ B硬币的两面;即，作为朋友和敌人。(C)2004年爱思唯尔公司All rights reserved.
Nuclear transcription factor NF-kappaB, initially discovered as a factor in the nucleus of B cells that binds to the enhancer of the kappa light chain of immunoglobulin, has since been shown to be expressed ubiquitously in the cytoplasm of all cell types, conserved from Drosophila to man. It translocates to the nucleus only when activated, where it regulates the expression of over 200 genes that control the immune system, growth, and inflammation. The dysregulation of NF-kappaB can mediate a wide variety of diseases including cancer. Whether NF-kappaB activation is beneficial or harmful for cancer is controversial. The development of novel therapeutics targeting NF-kappaB requires full understanding of its role in pathology and physiology. The current review is an attempt to describe two sides of the NF-kappaB coin; viz, as a friend and as a foe. (C) 2004 Elsevier Inc. All rights reserved.