Increasing Colorectal Cancer Incidence Before and After Age 50: Implications for Screening Initiation and Promotion of "On-Time" Screening.
Increasing Colorectal Cancer Incidence Before and After Age 50: Implications for Screening Initiation and Promotion of "On-Time" Screening.
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DOI：
10.1007/s10620-021-07213-w
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发表时间：
2022-08
影响因子：
3.1
通讯作者：
Gupta, Samir
中科院分区：
文献类型：
--
作者：
Cho, Moo Y.;Siegel, David A.;Demb, Joshua;Richardson, Lisa C.;Gupta, Samir
关键词：
50 岁以下的早发性结直肠癌 (CRC) 发病率呈上升趋势，出生队列效应导致 1950 年及以后出生的个体发病率上升。目前尚不清楚发病率趋势的增加是否会导致 50 岁以上的风险增加，50 岁是之前最常推荐的开始筛查年龄，此时筛查的可用性可能会改变发病率趋势。评估美国 40-59 岁人群结直肠癌 (CRC) 的趋势。我们使用覆盖 2003 年至 2017 年 100% 人口的美国癌症统计数据集分析了 CRC 的计数和发病率，包括按解剖学亚位点进行分析。连接点回归用于量化按年龄亚组划分的癌症发病率的年均百分比变化 (AAPC)。 470,458 例 40-59 岁的结直肠癌病例被观察，其中 50-54 岁每年直肠癌 (n = 4173) 和远端病例 (n = 3327) 的绝对数量接近 55-59 岁直肠 (n = 4566) 和远端 (n = 3682) 病例2017 年。据观察，50 岁以下的每 10 万人中早发直肠癌发病率的增加一直持续到 50-54 岁，40-44 岁从 4.9 升至 6.3（AAPC 2.1；95% CI 1.5-2.7），45-49 岁从 9.3 升至 12.0（AAPC 1.5；95% CI 1.1–1.4），50–54 岁为 16.7 至 19.5（AAPC 1.0；95% CI 0.7–1.3）。 CRC 趋势表明，观察到 50 岁以下人群的风险增加在 50 岁之后也存在，尽管之前对该群体进行了筛查。最近的 CRC 趋势支持在 50 岁之前开始筛查，并提倡“按时”开始筛查。
Early onset colorectal cancer (CRC) incidence is rising under age 50, with a birth cohort effect for increasing incidence among individuals born 1950 and later. It is unclear whether increasing incidence trends will confer increased risk beyond age 50, the previously most commonly recommended age to initiate screening, when screening availability might modify incidence trends. Evaluate US trends in colorectal cancer (CRC) for ages 40–59 years. We analyzed counts and incidence rates for CRC, including by anatomic subsite, using the US Cancer Statistics dataset covering 100% of the population 2003–2017. Joinpoint regression was used to quantify Average Annual Percent Change (AAPC) in cancer incidence by age subgroup. 470,458 CRC cases were observed age 40–59, with absolute numbers of rectal (n = 4173) and distal cases (n = 3327) per year for age 50–54 approaching age 55–59 cases for rectal (n = 4566) and distal (n = 3682) cancer by 2017. Increasing early onset rectal cancer incidence per 100,000 occuring under age 50 was observed to extend to age 50–54, from 4.9 to 6.3 for age 40–44 (AAPC 2.1; 95% CI 1.5–2.7), 9.3 to 12.0 for age 45–49 (AAPC 1.5; 95% CI 1.1–1.4), and from 16.7 to 19.5 for age 50–54 (AAPC 1.0; 95% CI 0.7–1.3). CRC trends suggest observed increased risks under age 50 are also present after age 50, despite prior availability of screening for this group. Recent CRC trends support initiation of screening earlier than age 50, and promotion of “on-time” screening initiation.
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影响因子：
7.7
作者：
Rex, Douglas K.;Boland, C. Richard;Robertson, Douglas J.
通讯作者：
Robertson, Douglas J.
DOI：
10.6004/jnccn.2018.0067
发表时间：
2018-08-01
影响因子：
13.4
作者：
Provenzale, Dawn;Gupta, Samir;Ogba, Ndiya
通讯作者：
Ogba, Ndiya
影响因子：
10.3
作者：
Siegel, Rebecca L.;Fedewa, Stacey A.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
9.8
作者：
Shaukat, Aasma;Kahi, Charles J.;Rex, Douglas K.
通讯作者：
Rex, Douglas K.
影响因子：
254.7
作者：
Wolf, Andrew M. D.;Fontham, Elizabeth T. H.;Smith, Robert A.
通讯作者：
Smith, Robert A.