Notch and Wnt signaling in the emergence of hematopoietic stem cells
Notch and Wnt signaling in the emergence of hematopoietic stem cells
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DOI：
10.1016/j.bcmd.2013.07.005
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发表时间：
2013-12-01
影响因子：
2.3
通讯作者：
Gama-Norton, Leonor
中科院分区：
文献类型：
--
作者：
Bigas, Anna;Guiu, Jordi;Gama-Norton, Leonor
造血干细胞（HSC）是存在于成年哺乳动物骨髓中并在生物体的一生中维持造血的细胞，其在胚胎发育期间被指定并产生。我们刚刚开始了解HSC是如何从更原始的细胞发展而来的，以及所涉及的信号通路的复杂性。在这项工作中，我们回顾了两个关键的途径，Notch和Wnt，在HSC的规格和发展及其新生的微环境，动脉血管的作用。(C)2013爱思唯尔公司All rights reserved.
Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels. (C) 2013 Elsevier Inc. All rights reserved.