Monodisperse nanoparticles of poly(ethylene glycol) macromers and N-isopropyl acrylamide for biomedical applications
Monodisperse nanoparticles of poly(ethylene glycol) macromers and N-isopropyl acrylamide for biomedical applications
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DOI：
10.1002/app.11612
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发表时间：
2003-03-07
影响因子：
3
通讯作者：
Peppas, NA
中科院分区：
文献类型：
--
作者：
Leobandung, W;Ichikawa, H;Peppas, NA
基于聚乙二醇的纳米颗粒在生物医学领域受到了极大的关注。当它们与pH或温度敏感的共聚单体共聚时，它们的小尺寸使它们能够非常迅速地响应环境的变化，包括pH值，离子强度和温度的变化。此外，高的表面积与体积比使它们高度官能化。在这项工作中，由温度敏感的聚（N-异丙基丙烯酰胺），聚（乙二醇）400二甲基丙烯酸酯，和聚（乙二醇）1000甲基丙烯酸酯的纳米粒子组成的热引发，自由基分散聚合方法制备。利用光子相关光谱法研究了水凝胶纳米粒子的粒径大小，并对水凝胶纳米粒子的温度响应行为进行了表征。纳米颗粒的尺寸从200到1100 nm不等，并且是系统温度的强函数，从5到40 ℃。还研究了热、结构和形态特征。(C)2002 Wiley Periodicals，Inc.
Poly(ethylene glycol)-based nanoparticles have received significant attention in the field of biomedicine. When they are copolymerized with pH- or temperature-sensitive comonomers, their small size allows them to respond very quickly to changes in the environment, including changes in the pH, ionic strength, and temperature. In addition, the high surface-to-volume ratio makes them highly functionalized. In this work, nanoparticles composed of temperature-sensitive poly(N-isopropylacrylamide), poly(ethylene glycol) 400 dimethacrylate, and poly(ethylene glycol) 1000 methacrylate were prepared by a thermally initiated, free-radical dispersion polymerization method. The temperature-responsive behavior of the hydrogel nanoparticles was characterized by the study of their particle size with photon correlation spectroscopy. The size of the nanoparticles varied from 200 to 1100 nm and was a strong function of the temperature of the system, from 5 to 40degreesC. The thermal, structural, and morphological characteristics were also investigated. (C) 2002 Wiley Periodicals, Inc.