Gamma hydroxybutyrate in the monkey
Gamma hydroxybutyrate in the monkey
复制标题
猴子体内的γ羟基丁酸
作者：
O. Snead
用γ-羟基丁酸（GHB）静脉注射给猴，这些猴已口服各种抗惊厥药物或不同剂量水平的左旋多巴（L-DOPA）2周。连续脑电图（EEG）监测期间和之后GHB管理。分析血液中的GHB和动物正在接受的抗惊厥药物。乙琥胺和苯巴比妥可改善GHB引起的脑电图和行为学改变，苯妥英可加重GHB引起的脑电图和行为学改变，左旋多巴对GHB引起的脑电图和行为学改变无影响。
Gamma hydroxybutyrate (GHB) was administered intravenously to monkeys that had been pretreated orally for 2 weeks with various anticonvulsant drugs or with L-DOPA at different dosage levels. Continuous electroencephalographic (EEG) monitoring was performed during and after GHB administration. Blood was assayed for GHB and for the anticonvulsant drug the animal was receiving. The EEG and behavioral changes produced by GHB were improved by ethosuximide and phenobarbital, made worse by phenytoin, and unchanged by L-DOPA.