The impact of educational materials on compliance and persistence rates with adjuvant aromatase inhibitor treatment: First-year results from the Compliance of ARomatase Inhibitors AssessmenT In Daily practice through Educational approach (CARIATIDE) study

The impact of educational materials on compliance and persistence rates with adjuvant aromatase inhibitor treatment: First-year results from the Compliance of ARomatase Inhibitors AssessmenT In Daily practice through Educational approach (CARIATIDE) study
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DOI：
10.1016/j.breast.2014.02.009
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发表时间：
2014-08-01
期刊：
BREAST
影响因子：
3.9
通讯作者：
Deschamp, Veronique
Deschamp, Veronique
中科院分区：
医学2区
文献类型：
--
作者：
Neven, Patrick;Markopoulos, Christos;Deschamp, Veronique

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CARIATIDE 研究旨在评估教育材料 (EM) 对患有激素受体阳性早期乳腺癌的绝经后女性芳香酶抑制剂 (AI) 治疗的依从性和持续率的影响。患者被随机分配接受标准 AI 治疗（A 组；N = 1379）或标准 AI 治疗加包含一系列乳腺癌相关主题信息的 EM（B 组；N = 1379）。标准化问卷评估了研究者感知的护理水平并评估了患者的依从性和行为。 1 年时，A 组和 B 组之间的依从性没有显着差异（81% vs. 82%，p = 0.4524）。然而，在瑞典/芬兰观察到接受 EM 的患者依从性较高 (p = 0.0246)。 EM 并未显着改变对初始 AI 的依从性和持续率。与提高依从性相关的其他因素，无论新兴市场如何，例如确定了化疗的施用。 (C) 2014 Elsevier Ltd. 保留所有权利。
The CARIATIDE study was designed to assess the impact of educational materials (EMs) on compliance and persistence rates with aromatase inhibitor (AI) treatment in postmenopausal women with hormone-receptor-positive early breast cancer. Patients were randomized to standard AI treatment (Group A; N = 1379) or standard AI treatment plus EMs containing information on a range of breast-cancer-related topics (Group B; N = 1379). Standardized questionnaires assessed investigator-perceived levels of care and evaluated patient compliance and behavior. At 1 year, there was no significant difference in compliance between Group A and Group B (81% vs. 82%, p = 0.4524). However, higher compliance in patients receiving EMs was observed in Sweden/Finland (p = 0.0246). Compliance with initial AI and persistence rate were not significantly altered by EM. Other factors associated with improved compliance, irrespective of EMs, e.g. administration of chemotherapy were identified. (C) 2014 Elsevier Ltd. All rights reserved.