Cardiopulmonary exercise testing for prognosis in chronic heart failure:: continuous and independent prognostic value from VE/VCO2 slope and peak VO2
Cardiopulmonary exercise testing for prognosis in chronic heart failure:: continuous and independent prognostic value from VE/VCO2 slope and peak VO2
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DOI：
10.1053/euhj.1999.1863
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发表时间：
2000-01-01
影响因子：
39.3
通讯作者：
Coats, AJS
中科院分区：
文献类型：
--
作者：
Francis, DP;Shamim, W;Coats, AJS
背景慢性心力衰竭预后不良。心脏运动试验对预测存活率很有用。方法和结果1992年至1996年连续303例稳定性慢性心力衰竭患者进行了心肺运动试验，他们的年龄为59 ± 11岁（平均值± SD），峰值VO 2 17.8 ± 66 ml。kg（-1）min（-1）。VE/VCO 2斜率37 +/- 12。在1999年1月随访结束时，91例患者死亡（中位7个月后，四分位距3-16个月）。存活者的中位随访时间为47个月（四分位距37-57个月）。预测2年死亡率的受试者工作特征曲线下面积对于峰值VO 2和VE/VCO 2斜率均为0.77。在考克斯比例风险模型中，将峰值VO 2和VE/VCO 2斜率视为连续变量，无论是在单变量分析还是双变量分析中，它们都是高度显著的预后指标（P
Background Chronic heart failure carries a poor prognosis. Cardiopulmonary exercise testing is useful in predicting survival. We set out to establish the prognostic value of peak VO2 and VE/VCO2 slope across a range of threshold values.Method and Results Three hundred and three consecutive patients with stable chronic heart failure underwent cardiopulmonary exercise testing between 1992 and 1996, Their age was 59 +/- 11 years (mean +/- SD), peak VO2 17.8 +/- 66 ml. kg(-1) min(-1). VE/VCO2 slope 37 +/- 12. Al the end of follow-up in January 1999, 91 patients had died (after a median of 7 months, interquartile range 3-16 months). The median follow-up for the survivors was 47 months (interquartile range 37-57 months). The areas under the receiver-operating characteristic curves for predicting mortality at 2 years were 0.77 for both peak VO2 and VE/VCO2 slope. With peak VO2 and VE/VCO2 slope viewed as continuous variables in the Cox proportional-hazards model, they were both highly significant prognostic indicators, both in univariate analysis and bivariate analysis (P