RYANODINE RECEPTOR ADAPTATION - CONTROL MECHANISM OF CA2+-INDUCED CA2+ RELEASE IN HEART
RYANODINE RECEPTOR ADAPTATION - CONTROL MECHANISM OF CA2+-INDUCED CA2+ RELEASE IN HEART
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DOI：
10.1126/science.8387229
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发表时间：
1993-05-07
期刊：
影响因子：
56.9
通讯作者：
FILL, M
中科院分区：
文献类型：
--
作者：
GYORKE, S;FILL, M
单心脏ryanodine受体（RyR）通道的适应证明了应用笼钙离子（Ca 2+）的方法。与表面膜配体门控通道中发现的常规脱敏相反，单个心脏RyR通道适应于维持Ca2+刺激，保留其对第二（更大）Ca2+刺激作出反应的能力。RyR适应可能代表了心脏中平稳分级Ca2+诱导的Ca2+释放的分子控制机制，并且可能是通道的基本特征，包括三磷酸肌醇受体，其参与许多细胞类型中的细胞内Ca2+信号传导。
Adaptation of single cardiac ryanodine receptor (RyR) channels was demonstrated by application of the caged calcium ion (Ca2+) methodology. In contrast to conventional desensitization found in surface membrane ligand-gated channels, single cardiac RyR channels adapted to maintained Ca2+ stimuli, preserving their ability to respond to a second (larger) Ca2+ stimulus. RyR adaptation may represent a molecular control mechanism for smoothly graded Ca2+-induced Ca2+ release in heart and may be a fundamental feature of channels, including the inositol trisphosphate receptor, that are involved in intracellular Ca2+ signaling in many cell types.