Methamphetamine Consumption Inhibits Pair Bonding and Hypothalamic Oxytocin in Prairie Voles.
Methamphetamine Consumption Inhibits Pair Bonding and Hypothalamic Oxytocin in Prairie Voles.
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DOI：
10.1371/journal.pone.0158178
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Ryabinin AE
中科院分区：
文献类型：
--
作者：
Hostetler CM;Phillips TJ;Ryabinin AE
甲基苯丙胺（MA）滥用与暴力，冒险行为，性抑制减少和犯罪活动有关。了解这些药物作用的机制对于预防和治疗MA相关的社会问题非常重要。先前的研究已经证明，实验者管理的安非他明抑制配对结合，并增加一夫一妻制草原田鼠的攻击性。目前尚不清楚在自愿（主动）给药的条件下是否会对社会行为产生类似的影响。目前的研究调查了MA饮酒是否会影响配对关系以及参与的神经回路。在实验1中，我们暴露雄性和雌性田鼠4天，20和40 mg/L的MA下连续2瓶选择（2BC）程序。将动物单独饲养或与社会伴侣一起饲养在网格分隔的笼中。田鼠消耗MA在饮用水的解决方案，但MA饮用不受性别或住房条件。在实验2中，我们调查是否MA饮用破坏社会联系，通过测量侵略和合作伙伴的偏好形成后，连续三天的18小时/天的访问100毫克/L MA在2BC程序。虽然侵略一个新的异性动物不受MA曝光，合作伙伴的偏好被抑制在MA饮用动物。实验3研究了下丘脑神经肽的改变是否为实验2中观察到的伴侣偏好抑制提供了潜在的解释。MA饮酒导致下丘脑室旁核催产素显著减少，但不包括加压素。这些实验是第一次调查自愿预暴露于MA如何影响社会一夫一妻制物种的社会依恋的发展，并确定参与这些影响的潜在神经回路。
Methamphetamine (MA) abuse has been linked to violence, risk-taking behaviors, decreased sexual inhibition, and criminal activity. It is important to understand mechanisms underlying these drug effects for prevention and treatment of MA-associated social problems. Previous studies have demonstrated that experimenter-administered amphetamine inhibits pair bonding and increases aggression in monogamous prairie voles. It is not currently known whether similar effects on social behaviors would be obtained under conditions during which the drug is voluntarily (actively) administered. The current study investigated whether MA drinking affects pair bonding and what neurocircuits are engaged. In Experiment 1, we exposed male and female voles to 4 days each of 20 and 40 mg/L MA under a continuous 2-bottle choice (2BC) procedure. Animals were housed either singly or in mesh-divided cages with a social partner. Voles consumed MA in a drinking solution, but MA drinking was not affected by either sex or housing condition. In Experiment 2, we investigated whether MA drinking disrupts social bonding by measuring aggression and partner preference formation following three consecutive days of 18-hour/day access to 100 mg/L MA in a 2BC procedure. Although aggression toward a novel opposite-sex animal was not affected by MA exposure, partner preference was inhibited in MA drinking animals. Experiment 3 examined whether alterations in hypothalamic neuropeptides provide a potential explanation for the inhibition of partner preference observed in Experiment 2. MA drinking led to significant decreases in oxytocin, but not vasopressin, in the paraventricular nucleus of the hypothalamus. These experiments are the first investigation into how voluntary pre-exposure to MA affects the development of social attachment in a socially monogamous species and identify potential neural circuits involved in these effects.