Annotation inconsistencies beyond sequence similarity-based function prediction - phylogeny and genome structure.
Annotation inconsistencies beyond sequence similarity-based function prediction - phylogeny and genome structure.
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DOI：
10.1186/s40793-015-0101-2
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发表时间：
2015
影响因子：
--
通讯作者：
Ouzounis CA
中科院分区：
文献类型：
--
作者：
Promponas VJ;Iliopoulos I;Ouzounis CA
计算生物学中的功能注释过程已逐渐从蛋白质分子个体生化作用的传统表征转向整个代谢途径和基因组结构的全系统检测。所谓的基因组感知方法将基因组序列中的错误注释不一致扩大到蛋白质功能分配之外，涵盖系统发育异常和人为基因组区域。我们通过提供引人注目的示例，概述了数据库中的三类错误传播——从传统到新兴的社区不同程度的欣赏，从而提高了对未来解决方案的认识。
The function annotation process in computational biology has increasingly shifted from the traditional characterization of individual biochemical roles of protein molecules to the system-wide detection of entire metabolic pathways and genomic structures. The so-called genome-aware methods broaden misannotation inconsistencies in genome sequences beyond protein function assignments, encompassing phylogenetic anomalies and artifactual genomic regions. We outline three categories of error propagation in databases by providing striking examples – at various levels of appreciation by the community from traditional to emerging, thus raising awareness for future solutions.