REACTIVE ASTROCYTES EXPRESS THE EMBRYONIC INTERMEDIATE NEUROFILAMENT NESTIN
REACTIVE ASTROCYTES EXPRESS THE EMBRYONIC INTERMEDIATE NEUROFILAMENT NESTIN
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DOI：
10.1097/00001756-199410000-00011
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发表时间：
1994-10-03
期刊：
影响因子：
1.7
通讯作者：
TURNER, DA
中科院分区：
文献类型：
--
作者：
CLARKE, SR;SHETTY, AK;TURNER, DA
NESTIN是一种神经丝蛋白，由大鼠和人类神经元和神经胶质的直接前体表达。用海人酸（KA）损毁大鼠海马，观察其中枢神经系统巢蛋白（Nestin）的免疫反应。KA病变内大量巢蛋白阳性细胞经胶质细胞酸性蛋白（GFAP）免疫反应证实为反应性星形胶质细胞。这些细胞的数量随着KA损伤后的时间而减少，并且在对照动物中没有观察到星形胶质细胞对巢蛋白的免疫染色。室管膜下区巢蛋白阳性细胞的一个子集似乎是放射状胶质细胞，延伸到细胞体层。巢蛋白是由反应性星形胶质细胞表达的几种胚胎标志物之一，表明KA损伤诱导的胚胎逆转，可能增强功能恢复。
NESTIN is a neurofilament protein expressed by the immediate precursors to neurons and glia in rats and humans. Nestin immunoreactivity in the rat CNS was studied following kainic acid (KA) hippocampal lesions. Numerous nestin positive cells within the KA lesion were confirmed to be reactive astrocytes by their immunoreactivity for glial fibrillary acidic protein (GFAP). The number of these cells decreased with time after the KA lesion and no astrocyte immunostaining for nestin was observed in control animals. A subset of nestin-positive cells in the ventricular subependymal region appeared to be radial glial cells, extending to cell body layers. Nestin is one of several embryonic markers expressed by reactive astrocytes, suggesting an embryonic reversion induced by the KA lesion, possibly to enhance functional recovery.