Roles of lncRNAs in influenza virus infection
Roles of lncRNAs in influenza virus infection
复制标题
DOI：
10.1080/22221751.2020.1778429
复制
发表时间：
2020-01
影响因子：
13.2
通讯作者：
Jing Wang;S. Cen
中科院分区：
文献类型：
--
作者：
Jing Wang;S. Cen
摘要近年来的研究发现，宿主长链非编码RNA（lncRNA）是病毒感染过程中宿主与病毒相互作用的关键调节因子。甲型流感病毒仍然是对公共卫生和经济稳定的严重威胁。众所周知，成千上万的lncRNA在IAV感染后差异表达，其中一些通过调节宿主先天免疫应答、影响细胞代谢或直接与病毒蛋白相互作用来调节IAV感染。其中一些lncRNA似乎是IAV感染所必需的，但其分子机制尚未完全阐明。本文综述了宿主lncRNA在调控IAV感染中的作用，并对lncRNA介导的调控网络进行了综述。本文综述的目的是促进对已建立和新发现的lncRNA在IAV感染中的功能的进一步研究。
ABSTRACT Recent studies have identified host long noncoding RNAs (lncRNAs) as key regulators of host-virus interactions during viral infection. The influenza A virus (IAV) remains a serious threat to public health and economic stability. It is well known that thousands of lncRNAs are differentially expressed upon IAV infection, some of which regulate IAV infection by modulating the host innate immune response, affecting cellular metabolism, or directly interacting with viral proteins. Some of these lncRNAs appear to be required for IAV infection, but the molecular mechanisms are not completely elucidated. In this review, we summarize the roles of host lncRNAs in regulating IAV infection and provide an overview of the lncRNA-mediated regulatory network. The goal of this review is to stimulate further research on the function of both well-established and newly discovered lncRNAs in IAV infection.