TISSUE COMPATIBILITY OF DIFFERENT INTRACRANIAL IMPLANT MATERIALS - INVIVO AND INVITRO STUDIES
TISSUE COMPATIBILITY OF DIFFERENT INTRACRANIAL IMPLANT MATERIALS - INVIVO AND INVITRO STUDIES
复制标题
DOI：
10.1007/bf01406813
复制
发表时间：
1984-01-01
影响因子：
2.4
通讯作者：
AMMAR, A
中科院分区：
文献类型：
--
作者：
AMMAR, A
采用成纤维细胞组织培养法研究了不同颅内植入材料的组织相容性。将相同材料植入兔颅骨内2个月。兔颅骨不脱钙切片，包括材料，用品红和亚甲基蓝和Masson Goldner法染色。软X线检查新骨形成情况。所用材料为氧化铝陶瓷、羟基磷灰石陶瓷、甲基丙烯酸甲酯钛、Sugita动脉瘤夹、硅分流管和冻干人硬脑膜（Lyo-dura）。氧化铝陶瓷和羟基磷灰石陶瓷在体内实验中均表现出良好的组织相容性。氧化铝陶瓷具有良好的组织相容性，而羟基磷灰石陶瓷的组织相容性较差。实验前1周制备的甲基丙烯酸甲酯显示出优异的相容性，但在实验时制备的相同材料仅显示出一般的相容性。钛和硅分流管表现出良好的相容性。由elgiloy制成的Sugita动脉瘤夹显示出良好的相容性，而Lyo-dura在体外实验中显示出良好的相容性，但在体内实验中相容性较差。并对体内、体外实验结果差异的原因进行了讨论。
Tissue compatibility of different intracranial implant materials was studied by a tissue culture method using fibroblasts. The same materials were implanted in the crania of rabbits for 2 mo. Undecalcified sections of rabbit crania, including the materials, were stained with Fuchsin and Methylene Blue and Masson-Goldner methods. Soft X-ray was used to detect new bone formation. The materials used were alumina ceramics, hydroxy apatite ceramics, Ti methylmethacrylate, Sugita aneurysm clip, Si shunt tube and lyophilized human dura mater (Lyo-dura). Both alumina ceramics and hydroxy apatite ceramics showed an excellent tissue compatibility in-vivo experiments. Although alumina ceramics showed an excellent tissue compatibility in in-vitro experiments, hydroxyl apatite ceramics showed less compatibility. Methylmethacrylate prepared 1 wk before the experiment showed excellent compatibility, but the same material prepared at the time of experiment showed only fair compatibility. The Ti and Si shunt tube showed excellent compatibility. The Sugita aneurysm clip, made from elgiloy, showed fair compatibility, while Lyo-dura showed excellent compatibility in in vitro experiments, but less compatibility in in vivo experiments. The reasons for the differences between the results of in vivo and in vitro experiments are discussed.