Risk for Hospitalization With Depression After a Cancer Diagnosis: A Nationwide, Population-Based Study of Cancer Patients in Denmark From 1973 to 2003
Risk for Hospitalization With Depression After a Cancer Diagnosis: A Nationwide, Population-Based Study of Cancer Patients in Denmark From 1973 to 2003
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DOI：
10.1200/jco.2008.20.5526
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发表时间：
2009-03-20
影响因子：
45.3
通讯作者：
Johansen, Christoffer
中科院分区：
文献类型：
--
作者：
Dalton, Susanne O.;Laursen, Thomas Munk;Johansen, Christoffer
随着越来越多的人从癌症中幸存下来，有必要了解癌症的长期影响。我们调查了癌症幸存者是否在住院治疗depression.MethodsWe的风险增加的数据，所有5,703,754人生活在丹麦1973年1月1日，或此后出生的丹麦癌症登记处，并确定了608,591成年人诊断为癌症。从1973年到2003年，丹麦精神病学中心登记处对因抑郁症住院的患者进行了随访，结果为121，227，396人-年和121，304例因抑郁症住院。通过Poisson回归分析估计癌症幸存者相对于无癌人群的抑郁相对风险（RR），调整年龄和时期，并按性别、癌症部位和疾病程度分层。（95% CI，0.90至1.51）在女性结直肠癌和3.08（95% CI，1.88至5.02）在男性脑癌。在随后的几年里，观察到大多数特定癌症的风险下降，但仍然显着过剩。在整个研究期间，男性和女性幸存的吸烟相关的癌症，女性幸存的吸烟相关的癌症，和男性幸存的病毒和免疫相关cancer.ConclusionThis研究证实了抑郁症的风险增加的患者面临的破坏性事件，如癌症。需要早期识别和有效治疗，以防止癌症幸存者因抑郁症入院。
PurposeAs more people survive cancer, it is necessary to understand the long-term impact of cancer. We investigated whether cancer survivors are at increased risk for hospitalization for depression.MethodsWe linked data on all 5,703,754 persons living in Denmark on January 1, 1973, or born thereafter to the Danish Cancer Registry and identified 608,591 adults with a diagnosis of cancer. Follow-up for hospitalization for depression in the Danish Psychiatric Central Register from 1973 through 2003 yielded 121,227,396 person-years and 121,304 hospitalizations for depression. The relative risk (RR) for depression among cancer survivors relative to the cancer-free population was estimated by Poisson regression analysis with adjustment for age and period and stratified by sex, site of cancer, and extent of disease.ResultsThe risk for depression in the first year after a cancer diagnosis was increased, with RRs ranging from 1.16 (95% CI, 0.90 to 1.51) in women with colorectal cancer to 3.08 (95% CI, 1.88 to 5.02) in men with brain cancer. Decreasing but still significant excess risks during subsequent years were observed for most specific cancers. The risk remained increased throughout the study period for both men and women surviving hormone-related cancers, for women surviving smoking-related cancers, and for men surviving virus- and immune-related cancers.ConclusionThis study confirms an increased risk for depression in patients facing a disruptive event like cancer. Early recognition and effective treatment are needed to prevent admission of cancer survivors for depression.