Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report.
Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report.
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DOI：
10.1016/s1470-2045(11)70175-9
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发表时间：
2012-01
期刊：
影响因子：
51.1
通讯作者：
Perrier, Arnaud
中科院分区：
文献类型：
--
作者：
Clavien, Pierre-Alain;Lesurtel, Mickael;Bossuyt, Patrick M. M.;Gores, Gregory J.;Langer, Bernard;Perrier, Arnaud
虽然肝移植是一种被广泛接受的治疗肝细胞癌（HCC）的方法，但仍存在许多争议，并且没有一套普遍接受的指南。2010年12月2-4日在瑞士苏黎世举行了一次国际共识会议，目的是审查HCC患者肝移植的当前实践，并制定国际公认的声明和指南。会议的形式以丹麦模式为基础。19个专家工作组根据牛津分类法编写了循证综述，并起草了回答19个具体问题的建议。任命了一个由九名成员组成的独立评审团，在与专家和与会者进行辩论后，对这些提交的材料进行审查，并提出最终建议。本报告提出了最终的37项声明和建议，涵盖肝移植候选人的评估、肝硬化和非肝硬化患者的列名标准、肿瘤降级的作用、等候名单上患者的管理、活体捐赠的作用和移植后管理。
Although liver transplantation is a widely accepted treatment for hepatocellular carcinoma (HCC), much controversy remains and there is no generally accepted set of guidelines. An international consensus conference was held on Dec 2–4, 2010, in Zurich, Switzerland, with the aim of reviewing current practice regarding liver transplantation in patients with HCC and to develop internationally accepted statements and guidelines. The format of the conference was based on the Danish model. 19 working groups of experts prepared evidence-based reviews according to the Oxford classification, and drafted recommendations answering 19 specific questions. An independent jury of nine members was appointed to review these submissions and make final recommendations, after debates with the experts and audience at the conference. This report presents the final 37 statements and recommendations, covering assessment of candidates for liver transplantation, criteria for listing in cirrhotic and non-cirrhotic patients, role of tumour downstaging, management of patients on the waiting list, role of living donation, and post-transplant management.