Unnatural natural products from the transannular cyclization of lathyrane diterpenes
Unnatural natural products from the transannular cyclization of lathyrane diterpenes
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DOI：
10.1021/ol0155541
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发表时间：
2001-05-31
期刊：
影响因子：
5.2
通讯作者：
Sterner, O
中科院分区：
文献类型：
--
作者：
Appendino, G;Tron, GC;Sterner, O
[图解]大环二萜类化合物具有提供类似多环化合物的天然产物的潜力，这是通过将两个赖氨基大戟因子转化为一系列非天然骨架类型的稠密官能化的二萜类化合物而得到的。显然，大自然还远远没有充分利用这些化合物的内在反应性来产生化学多样性。
[GRAPHICS]The potential of macrocyclic diterpenoids to afford natural product like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.