Aurora-A amplification associated with BRCA2 mutation in breast tumours
Aurora-A amplification associated with BRCA2 mutation in breast tumours
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DOI：
10.1016/j.canlet.2006.06.003
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发表时间：
2007-04-08
期刊：
影响因子：
9.7
通讯作者：
Eyfjord, Jorunn E.
中科院分区：
文献类型：
--
作者：
Bodvarsdottir, Sigridur K.;Hilmarsdottir, Holmfridur;Eyfjord, Jorunn E.
在BRCA2 999del5突变携带者（n = 20）和非携带者（n = 41）的乳腺肿瘤中检测了Aurora-A扩增与BRCA2突变的潜在相互作用。FISH研究的Aurora-A扩增在BRCA2突变携带者的乳腺肿瘤中更为常见（p = 0.0005）。在三个具有相同BRCA2突变的乳腺上皮细胞系的中期染色体上也检测到广泛的Aurora-A扩增。此外，在非brca2突变载体肿瘤中，Aurora-A扩增与TP53突变之间存在显著关联（p = 0.007）。这些结果表明，BRCA2或TP53突变的乳腺肿瘤可能是Aurora-A靶向治疗的有希望的候选者。2006爱思唯尔爱尔兰有限公司版权所有。
Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n = 20) and non-carriers (n = 41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p = 0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with the same BRCA2 mutation. In addition, significant association was found between Aurora-A amplification and TP53 mutations in non-BRCA2 mutation carrier tumours (p = 0.007). These results suggest that breast tumours with mutations in BRCA2 or TP53 could be promising candidates for Aurora-A targeted treatment. (c) 2006 Elsevier Ireland Ltd. All rights reserved.