Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice
Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice
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DOI：
10.1016/j.cellbi.2007.04.001
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发表时间：
2007-10-01
影响因子：
3.9
通讯作者：
Matsuo, Osamu
中科院分区：
文献类型：
--
作者：
Otaki, Sayuri;Ueshima, Shigeru;Matsuo, Osamu
组织工程技术是为修复组织缺损而发展起来的。这项新技术需要制造组织的细胞。骨髓间充质干细胞已被用作该技术的细胞来源，然而，牙髓细胞最近已被证明具有干细胞样properties. We早期证明，牙髓细胞增殖，并产生细胞外基质，随后成为矿化体外。我们现在报告，这种牙髓细胞（第一至第八代）产生骨，而不是牙本质时，这些细胞植入免疫功能低下的小鼠与HA/TCP粉末作为其载体的皮下部位。牙髓细胞是成牙本质细胞和成骨细胞的共同祖细胞，或者说牙髓细胞本身就是间充质干细胞，有望成为组织工程的候选细胞来源，并为修复受损或病变组织提供新的治疗途径。(c)2007年国际细胞生物学联合会。由爱思唯尔有限公司出版。保留所有权利。
The technique of tissue engineering is developing for the restoration of lost tissues. This new technique requires cells that fabricate tissue. Mesenchymal stem cells in bone marrow have been used as the cell source for this technique; however, dental pulp cells have recently been shown to possess stem-cell-like properties.We earlier demonstrated that dental pulp cells proliferate and produce an extracellular matrix that subsequently becomes mineralized in vitro. We now report that such dental pulp cells (first to eighth passage) produced bone instead of dentin when those cells were implanted into subcutaneous sites in immunocompromised mice with HA/TCP powder as their carrier. This evidence shows that dental pulp cells are the common progenitors of odontoblasts and osteoblasts, or dental pulp cells are mesenchymal stem cells themselves.It is expected that dental pulp cells can be a useful candidate cell source for tissue engineering, and contain the potential of new therapeutic approaches for the restoration of damaged or diseased tissue. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.