Randomized diet in the neonatal period and growth performance until 7.5-8 y of age in preterm children.
Randomized diet in the neonatal period and growth performance until 7.5-8 y of age in preterm children.
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DOI：
10.1093/ajcn/71.3.822
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发表时间：
2000-03
期刊：
影响因子：
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通讯作者：
Ruth Morley;Alan Lucas
中科院分区：
文献类型：
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作者：
Ruth Morley;Alan Lucas
早产儿生长发育不良的风险很高。在2项随机试验中，喂食早产儿配方奶粉的早产儿在新生儿期的生长状况优于喂食库存捐赠母乳或标准足月配方奶粉的早产儿。目的：我们的目的是检验这一假设，即早产儿，新生儿期是一个关键的编程生长性能和早期饮食影响长期的增长。设计926名早产儿被纳入2个平行、随机的新生儿饮食试验。在试验1中，婴儿被喂食母乳或早产儿配方奶粉，而在试验2中，婴儿被喂食标准足月配方奶粉或早产儿配方奶粉。在每项试验中，分配的乳汁是一些婴儿的唯一饮食（研究A），而对于其他婴儿，它是母亲母乳的补充，当没有足够的挤出母乳时提供（研究B）。我们随访了833名幸存者中的781名（94%），年龄为7.5-8岁。经过培训的评估员根据标准方案获得人体测量结果。结果：尽管喂养早产儿配方奶粉的新生儿生长表现明显优于母乳或标准配方奶粉，但早期饮食对出生后9或18个月或7.5-8岁时的体重、身高、头围或皮褶厚度没有影响。结论：这些发现表明，早产期不是营养计划生长的关键窗口，这与这些试验的证据形成对比，表明早期饮食影响后期神经发育。
BACKGROUND Preterm children are at high risk of poor growth performance. In 2 randomized trials, preterm infants fed preterm formula grew better in the neonatal period than those fed banked donor breast milk or standard term formula. OBJECTIVE Our objective was to test the hypothesis that for preterm infants, the neonatal period is a critical one for programming growth performance and that early diet influences long-term growth. DESIGN A total of 926 preterm infants were recruited into 2 parallel, randomized trials of neonatal diet. In trial 1, infants were fed either banked donor breast milk or preterm formula whereas in trial 2, infants were fed either standard term formula or preterm formula. Within each trial, the allocated milk was the sole diet for some infants (study A), whereas for others it was a supplement to maternal breast milk, given when not enough expressed breast milk was available (study B). We followed up 781 of 833 survivors (94%) to age 7.5-8 y. Trained assessors obtained anthropometric measurements according to a standard protocol. RESULTS Despite significantly better neonatal growth performance in infants fed preterm formula (compared with either banked donor breast milk or standard formula), early diet had no influence on weight, height, head circumference, or skinfold thicknesses at 9 or 18 mo postterm or at age 7.5-8 y. CONCLUSIONS These findings suggest that the preterm period is not a critical window for nutritional programming of growth, which contrasts with evidence from these trials showing that early diet influences later neurodevelopment.