ENHANCED MUSCLE GLUCOSE-METABOLISM AFTER EXERCISE - MODULATION BY LOCAL FACTORS
ENHANCED MUSCLE GLUCOSE-METABOLISM AFTER EXERCISE - MODULATION BY LOCAL FACTORS
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DOI：
10.1152/ajpendo.1984.246.6.e476
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发表时间：
1984-01-01
影响因子：
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通讯作者：
RUDERMAN, NB
中科院分区：
文献类型：
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作者：
RICHTER, EA;GARETTO, LP;RUDERMAN, NB
对大鼠的研究表明，在自愿运动后，骨骼肌中的糖原补充有两个阶段（先前的研究）。在第一阶段，葡萄糖利用和糖原合成的增强，在存在和不存在的胰岛素，而在第二阶段，只有在胰岛素的存在下的增加被发现。为了确定这些变化，特别是那些由胰岛素介导的是由于局部或全身因素，1麻醉大鼠的后肢进行电刺激，两个后肢灌注后立即。受刺激的腿中的葡萄糖和糖原代谢与先前在跑步机上自愿运动后观察到的代谢非常相似。在灌注液中不加入胰岛素的情况下，糖原耗尽的肌肉中葡萄糖掺入糖原的能力显著增强，2-脱氧葡萄糖和3-O-甲基葡萄糖的摄取也是如此。同样，胰岛素对这些过程的刺激增强，并且在2小时后，当受刺激腿的肌肉基本上充满了它们的糖原储存时，这种刺激继续存在。运动后胰岛素介导的葡萄糖利用和糖原合成的增加明显受到局部收缩诱导因子的调节。
Studies in the rat suggest that after voluntary exercise there are 2 phases of glycogen repletion in skeletal muscle (preceding study). In phase I glucose utilization and glycogen synthesis are enhanced both in the presence and absence of insulin, whereas in phase II only the increase in the presence of insulin is found. To determine whether these alterations and in particular those mediated by insulin are due to local or systemic factors, 1 hindlimb of an anesthetized rat was electrically stimulated and both hindlimbs were perfused immediately thereafter. Glucose and glycogen metabolism in the stimulated leg closely mimicked that observed previously after voluntary exercise on a treadmill. With no insulin added to the perfusate, glucose incorporation into glycogen was markedly enhanced in muscles that were glycogen depleted as were the uptake of 2-deoxyglucose and 3-O-methylglucose. Likewise, the stimulation of these processes by insulin was enhanced and continued to be so 2 h later when the muscles of the stimulated leg had substantially repleted their glycogen stores. Increases in insulin-mediated glucose utilization and glycogen synthesis in muscle after exercise evidently are modulated by local contraction-induced factors.