Transient spatial deficit associated with bilateral lesions of the lateral mammillary nuclei
Transient spatial deficit associated with bilateral lesions of the lateral mammillary nuclei
复制标题
与外侧乳头核双侧病变相关的短暂空间缺陷
DOI：
--
复制
发表时间：
2005
影响因子：
3.4
通讯作者：
S. Vann
中科院分区：
文献类型：
--
作者：
S. Vann
乳头体长期以来一直与空间记忆有关，该结构的损伤会损害大鼠的一些空间记忆任务。然而，乳头体包括两个具有不同电生理学和解剖学特性的主要核。因此，它们可能具有不同的功能。本研究确定是否选择性病变的这些组成部分之一，外侧乳头体核，足以引起空间记忆缺陷。虽然选择性外侧乳头体核病变引起的赤字在水迷宫中的工作记忆任务，这种损害是温和的，而不是持久的完整的乳头体病变。此外，乳头体外侧核病变不会损害T-迷宫交替，这对乳头体完全病变敏感。从这些结果看来，病变局限于外侧乳头核足以产生轻微的损害时，快速，新的空间学习是在溢价。与此同时，剩下的乳头状核也有助于空间学习，尽管这可能是以一种质的不同的方式。
The mammillary bodies have long been implicated in spatial memory, and lesions of this structure in rats can impair some spatial memory tasks. The mammillary bodies, however, comprise two main nuclei that have different electrophysiological and anatomical properties. It is therefore possible that they have different functions. The present study determined whether selective lesions of one of these components, the lateral mammillary nucleus, are sufficient to induce spatial memory deficits. While selective lateral mammillary nuclei lesions induced deficits on a working memory task in the water maze, this impairment was milder and not as persistent as that seen with complete mammillary body lesions. Furthermore, lateral mammillary nuclei lesions did not impair T‐maze alternation, which is sensitive to complete mammillary body lesions. From these results it appears that lesions confined to the lateral mammillary nuclei are sufficient to produce mild impairments when rapid, new spatial learning is at a premium. At the same time, the remaining mammillary nuclei also contribute to spatial learning, though this may be in a qualitatively different manner.
径向臂迷宫上头部方向细胞活动与空间行为之间的相关性。
影响因子：
1.9
作者：
Dudchenko,PA;Taube,JS
通讯作者：
Taube,JS