Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine
Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine
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DOI：
10.1016/j.jep.2005.08.017
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发表时间：
2006-02-20
影响因子：
5.4
通讯作者：
Hanaoka, K
中科院分区：
文献类型：
--
作者：
Shu, HH;Arita, H;Hanaoka, K
加工附子块茎（PAT）是一种草药，自古以来就被广泛用作止痛药。我们研究了亚镇痛剂量的 PAT 对小鼠吗啡耐受的影响。小鼠皮下注射吗啡 (10 mg/kg) 并口服亚镇痛剂量 (0.1 或 0.3 g/kg) 的 PAT，每天一次，持续 7 天。每日皮下注射后 60 分钟，使用尾压测试测量机械伤害感受阈值。吗啡注射剂。在安慰剂治疗组中，重复皮下注射给药。吗啡导致镇痛耐受的发展。在 PAT 治疗组中，口服 PAT 会减弱吗啡耐受性，呈剂量依赖性。 PAT 引起其耐受性减弱活性的主要成分生物碱是新乌头碱，但其他成分生物碱，如乌头碱和次乌头碱，也有助于这种活性。此外，重复使用 PAT 治疗可以逆转已经形成的吗啡耐受性。因此，口服 PAT 的亚镇痛剂量可以减弱和逆转小鼠的吗啡耐受性。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Processed Aconiti tuber (PAT) is a herbal medicine that has been widely used as an analgesic since ancient times. We investigated effects of subanalgesic doses of PAT on morphine tolerance in mice. Mice received subcutaneous morphine (10 mg/kg) and oral PAT at subanalgesic doses (0.1 or 0.3 g/kg), once a day for 7 days. Mechanical nociceptive thresholds were measured using the tail pressure test, at 60 min after the daily s.c. morphine injections. In the placebo-treated group, repeated administration of s.c. morphine resulted in development of analgesic tolerance. In the PAT-treated groups, oral PAT attenuated morphine tolerance, dose-dependently. The main ingredient alkaloid of PAT causing its tolerance-attenuating activity was mesaconitine, but other ingredient alkaloids, such as aconitine and hypaconitine, also contributed to this activity. In addition, repeated treatment with PAT could reverse already-developed morphine tolerance. Subanalgesic doses of oral PAT thus can attenuate and reverse morphine tolerance in mice. (c) 2005 Elsevier Ireland Ltd. All rights reserved.