The Origin and Fate of Muscle Satellite Cells
The Origin and Fate of Muscle Satellite Cells
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DOI：
10.1007/s12015-012-9352-0
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发表时间：
2012-06-01
影响因子：
4.8
通讯作者：
Dilworth, F. Jeffrey
中科院分区：
文献类型：
--
作者：
Aziz, Arif;Sebastian, Soji;Dilworth, F. Jeffrey
卫星细胞代表骨骼肌中的干细胞的主要群体。这些成体肌肉干细胞促进骨骼肌的出生后生长、重塑和再生。鉴于卫星细胞的显著再生潜力，用该细胞群治疗肌肉病变如肌营养不良症有很大的希望。已经开发了允许分离、富集和扩增卫星细胞衍生的肌肉干细胞的各种方案。然而，分离的卫星细胞尚未转化为有效的治疗干预模式。扩大我们对卫星细胞及其生态位要求的理解，应该可以改善我们对这些细胞的体内和体外操作，以加快它们用于病变肌肉的再生。本文探讨了卫星细胞的命运，这些细胞的命运是由其分子特征、个体发育和生态位依赖性编程决定的。
Satellite cells represent the primary population of stem cells resident in skeletal muscle. These adult muscle stem cells facilitate the postnatal growth, remodeling, and regeneration of skeletal muscle. Given the remarkable regenerative potential of satellite cells, there is great promise for treatment of muscle pathologies such as the muscular dystrophies with this cell population. Various protocols have been developed which allow for isolation, enrichment, and expansion of satellite cell derived muscle stem cells. However, isolated satellite cells have yet to translate into effective modalities for therapeutic intervention. Broadening our understanding of satellite cells and their niche requirements should improve our in vivo and ex vivo manipulation of these cells to expedite their use for regeneration of diseased muscle. This review explores the fates of satellite cells as determined by their molecular signatures, ontogeny, and niche dependent programming.