GLUCOCORTICOIDS POTENTIATE ISCHEMIC-INJURY TO NEURONS - THERAPEUTIC IMPLICATIONS
GLUCOCORTICOIDS POTENTIATE ISCHEMIC-INJURY TO NEURONS - THERAPEUTIC IMPLICATIONS
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DOI：
10.1126/science.4035356
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
PULSINELLI, WA
中科院分区：
文献类型：
--
作者：
SAPOLSKY, RM;PULSINELLI, WA
持续暴露于糖皮质激素（肾上腺皮质应激激素）对神经元是有毒的，并且这种毒性似乎在衰老期间的神经元损失中起作用。先前的研究表明，糖皮质激素损害神经元在各种代谢损伤中存活的能力。这份报告扩展了这些观察结果，表明缺血性损伤的神经元在大鼠大脑中也加强了暴露于高生理滴度的糖皮质激素，并减弱肾上腺切除术。缺血性脑损伤和糖皮质激素脑损伤之间的协同作用，即使在缺血性损伤后糖皮质激素水平被操纵。减少肾上腺皮质应激反应的药物干预可能会改善中风或心脏骤停的神经功能结局。
Sustained exposure to glucocorticoids, the adrenocortical stress hormones, is toxic to neurons, and such toxicity appears to play a role in neuron loss during aging. Previous work has shown that glucocorticoids compromise the capacity of neurons to survive a variety of metabolic insults. This reports extends those observations by showing that ischemic injury to neurons in rat brain is also potentiated by exposure to high physiological titers of glucocorticoids and is attenuated by adrenalectomy. The synergy between ischemic and glucocorticoid brain injury was seen even when glucocorticoid levels were manipulated after the ischemic insult. Pharmacological interventions that diminish the adrenocortical stress response may improve neurological outcome from stroke or cardiac arrest.