Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus
Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus
复制标题
双食欲素受体拮抗剂 (DORA-12) 治疗影响海马 Net/maoA mRNA 表达的总体水平
DOI：
10.1016/j.jphs.2020.12.003
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发表时间：
2021
影响因子：
3.5
通讯作者：
Nishimura Katsuji
中科院分区：
文献类型：
--
作者：
Moriya Shunpei;Takahashi Hitoshi;Masukawa Daiki;Yamada Makiko;Ishigooka Jun;Nishimura Katsuji
食欲能系统在调节适当的睡眠/觉醒维持方面发挥着重要作用。双重食欲素受体拮抗剂（DORA）被广泛用于失眠症状。拮抗剂作用于位于某些脑区的食欲素1和2受体，包括蓝斑和中缝背核。然而，其对单胺相关基因表达的影响尚不清楚。在这里，我们测量了DORA治疗小鼠中单胺相关基因的表达水平。DORA治疗显著影响海马中去甲肾上腺素转运体/单胺氧化酶AmRNA表达的总体水平。我们的研究结果表明，DORA有助于去甲肾上腺素相关的基因表达调控中枢神经系统。
The orexinergic system plays a significant role in regulating proper sleep/wake maintenance. Dual orexin receptor antagonist (DORA) is widely prescribed for insomnia symptoms. The antagonist acts on orexin 1 and 2 receptors located in certain brain areas, including the locus coeruleus and dorsal raphe. Nevertheless, its effects on monoamine-related gene expression remain unclear. Here, we measured the expression levels of monoamine-related genes in DORA-treated mice. DORA treatment significantly affected overall levels ofnoradrenalin transporter/monoamine oxidases AmRNA expression in the hippocampus. Our findings suggest that DORA contributes to noradrenalin-related gene expression regulation in the central nervous system.