Intestinal metaplasia of the gastric mucosa.
Intestinal metaplasia of the gastric mucosa.
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DOI：
10.1038/bjc.1955.35
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发表时间：
1955-09
影响因子：
8.8
通讯作者：
MORSON, B C
中科院分区：
文献类型：
--
作者：
MORSON, B C
在胃切除术标本的常规组织学检查中，无论是良性还是恶性，在胃粘膜中发现肠上皮区域并不罕见。在过去，胃粘膜中存在这种类型的上皮被认为是先天性异常（Hari，1901; Borrmann，1926; Taylor，1927;和Clar，1934）。然而，近年来大多数观察者支持胃粘膜中的肠上皮是由于胎后生活中的化生过程所致的观点（Geissendorfer，1928; Faber，1935; Magnus，1937; Stout，1943; Schindler，1947）。他们相信，用马格努斯的话来说，“。“胃中肠上皮的存在是胃炎反复损伤的粘膜中表面上皮的错误再生的结果，并且是由慢性刺激引起的化生的一个实例”。Warren和Meissner（1944）指出肠上皮化生的重要性，认为它是慢性胃炎的主要上皮特征。本文的目的是提请注意肠上皮化生的存在，并描述其发生率和范围在themucosa胃切除十二指肠溃疡，胃溃疡和癌。本研究中使用的所有材料包括十二指肠溃疡、胃溃疡和癌手术中取出的标本。它们细分如下：
DURING the routine histological examination of gastrectomy specimens re-moved for benign as well as malignant conditions it is not uncommon to find areas of intestinal epithelium in the gastric mucosa. The presence in the stomach lining of this type of epithelium has, in the past, been regarded as a congenital abnormality (Hari, 1901; Borrmann, 1926; Taylor, 1927; and Clar, 1934). However, the majority of observers inrecent years favour the view that the intestinal epithelium seen in the gastric mucosa is due to a process ofmetaplasia in post-foetal life (Geissendorfer, 1928; Faber, 1935; Magnus, 1937; Stout, 1943; Schindler, 1947). They believe, in the words of Magnus, that'.'the presence of intestinal epithelium in the stomach is the result of faulty regeneration of surface epithelium in a mucosa repeatedly damaged by gastritis, and is an example of metaplasia resulting from chronic irritation". The importance of intestinal metaplasia has been pointed out by Warren and Meissner (1944) who regard it as the chief epithelial feature of chronic gastritis. The purpose of this paper is to draw attention to the existence of intestinal metaplasia and to describe its incidence and extent in themucosa of stomachs removed surgically for duodenal ulcer, gastric ulcer and carcinoma.MATERIAL AND METHODS. All the material used in this investigation consists of specimens removed at operations for duodenal ulcer, gastric ulcer and carcinoma. They are subdivided as follows: