SEPTATE JUNCTIONS IN IMAGINAL DISKS OF DROSOPHILA - A MODEL FOR THE REDISTRIBUTION OF SEPTA DURING CELL REARRANGEMENT
SEPTATE JUNCTIONS IN IMAGINAL DISKS OF DROSOPHILA - A MODEL FOR THE REDISTRIBUTION OF SEPTA DURING CELL REARRANGEMENT
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DOI：
10.1083/jcb.94.1.77
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发表时间：
1982-01-01
影响因子：
7.8
通讯作者：
FRISTROM, DK
中科院分区：
文献类型：
--
作者：
FRISTROM, DK
组织的分隔连接在形态发生的成虫盘描述冷冻断裂副本和薄切片，以了解交界处的上皮细胞重排过程中的调制。椎间盘每个潜在细胞的分隔连接分布在与相邻细胞数量相等的离散区域中。单个隔膜穿过相邻细胞对之间的接触域，在域的侧边界处向下转向，并平行于与第三个细胞的交叉点。这种排列在3细胞交叉处留下小通道，这些通道被称为三细胞栓的专门结构占据。细胞重排涉及相邻细胞之间的接触域宽度的渐进变化，直到旧的接触被打破并建立新的接触。分隔连接通过现有分隔的压缩或延伸来调整域的宽度。这种隔膜的重新分布理论上允许在细胞重排期间维持跨上皮屏障。该模型对其他上皮组织的适用性进行了讨论。
The organization of septate junctions during morphogenesis of imaginal discs is described from freeze-fracture replicas and thin sections with a view to understanding junction modulation during rearrangements of cells in epithelia. The septate junctions of each potential cell of the disc are distributed in a number of discrete domains equal to the number of neighboring cells. Individual septa traverse domains of contact between pairs of adjacent cells, turn downwards at the lateral boundary of the domain and run parallel to the intersection with a 3rd cell. This arrangement leaves small channels at 3-cell intersections that are occupied by specialized structures termed tricellular plugs. Cell rearrangement involves a progressive change in the width of contact domains between adjacent cells, until old contacts are broken and new ones established. The septate junction adjusts to the changing width of domains by the compaction or extension of existing septa. This redistribution of septa theoretically allows a transepithelial barrier to be maintained during cell rearrangements. The applicability of this model to other epithelial tissues is discussed.