Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata
Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata
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DOI：
10.1021/acs.jnatprod.8b00643
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发表时间：
2018-11-01
影响因子：
5.1
通讯作者：
Suenaga, Kiyotake
中科院分区：
文献类型：
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作者：
Iwasaki, Arihiro;Tadenuma, Takato;Suenaga, Kiyotake
Hoshinoamides A（1）和B（2）是从海洋蓝藻Caldora penicillata中分离得到的两种新的脂肽。通过光谱分析和降解反应鉴定了它们的结构。Hoshinoamides A（1）和B（2）在10 μ M时对HeLa细胞没有任何细胞毒性，但抑制恶性疟原虫的体外生长（IC 50分别为0.52和1.0 μ M）。
Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 mu M, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC50 = 0.52 and 1.0 mu M, respectively).