Human Intestinal Spirochaetosis in Two Ulcerative Colitis Patients
Human Intestinal Spirochaetosis in Two Ulcerative Colitis Patients
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DOI：
10.2169/internalmedicine.53.2386
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Matsuzaki, Yasushi
中科院分区：
文献类型：
--
作者：
Iwamoto, Junichi;Ogata, Sho;Matsuzaki, Yasushi
37岁男性和61岁男性溃疡性结肠炎患者的纵向和不规则形状溃疡性病变的结肠活检组织学检查显示所谓的“边缘形成”，这是典型的短螺旋体感染的发现。两例患者的阿尔博氏短螺旋体抗体滴度均明显升高，均给予甲硝唑1000mg治疗14天。治疗后进行的结肠镜检查显示两名患者的溃疡病变均有改善。这些结果表明，肠道螺旋体感染应被视为溃疡性结肠炎患者长期接受类固醇治疗的感染性并发症的可能性。
A histological examination of colonic biopsies of the longitudinal and irregularly-shaped ulcerative lesions of a 37-year-old man and 61-year-old man with ulcerative colitis showed so-called "fringe formation," a typical finding of Brachyspira infection. The antibody titer to Brachyspira aalborgi showed marked elevation in both cases, and the patients were each treated with 1,000 mg of metronidazole for 14 days. Colonoscopy performed after treatment showed an improvement in the ulcerative lesions in both patients. These results indicate the possibility that intestinal spirochaetosis infection should be considered as an infectious complication in patients with ulcerative colitis receiving long-term steroid therapy.