Highly enantioselective insertion of carbenoids into N-H bonds catalyzed by copper complexes of chiral spiro bisoxazolines
Highly enantioselective insertion of carbenoids into N-H bonds catalyzed by copper complexes of chiral spiro bisoxazolines
复制标题
手性螺双恶唑啉铜配合物催化类胡萝卜素高度对映选择性插入 N-H 键
DOI：
10.1021/ja0711765
复制
发表时间：
2007-05-09
影响因子：
15
通讯作者：
Zhou, Qi-Lin
中科院分区：
文献类型：
--
作者：
Liu, Bin;Zhu, Shou-Fei;Zhou, Qi-Lin
通过手性螺环双恶唑啉配体实现了铜催化的α-重氮酯在N-H键上的高效不对称插入，高产率地得到了具有良好对映选择性的α-氨基酸衍生物。
A highly efficient copper-catalyzed asymmetric insertion of alpha-diazoesters into N-H bonds has been realized by using chiral spiro bisoxazoline ligands, affording alpha-amino acid derivatives in high yields with excellent enantioselectivities.