Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study.
Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study.
复制标题
在一项为期 10 年的前瞻性研究中，血清肝细胞生长因子水平升高与胰岛素抵抗的发展存在独立关联。
DOI：
10.1111/j.1365-2265.2012.04496.x
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Imaizumi T.
中科院分区：
文献类型：
--
作者：
Tsukagawa E;Adachi H;Hirai Y;Enomoto M;Fukami A;Ogata K;Kasahara A;Yokoi K;Imaizumi T.
肝细胞生长因子（HGF）受体与小鼠肝脏中的胰岛素受体形成杂合复合物，导致强大的信号传导来调节葡萄糖代谢。在患有代谢综合征和/或肥胖症的受试者中，血清HGF水平高。因此，我们前瞻性地研究了肝细胞生长因子和胰岛素抵抗（IR）的发展在一般人群中没有IR在baseline.MethodsA共1492例受试者接受健康检查之间的关系。在排除基线时患有糖尿病和/或IR的受试者（n= 402）后，剩余受试者（n= 1090）在10年后接受随访。716例受试者的完整数据集可用于前瞻性分析。结果在基线时无糖尿病的受试者中，IR患者血清HGF水平（0·26 ± 0·10 ng/ml，n= 259）高于无IR患者（0·22 ± 0·09 ng/ml，n= 1090）。在删除随访期间发生肝病的受试者后，发现188例在原始筛选后10年发生IR。多因素Logistic回归分析显示，HGF（P < 0·05）、年龄（P<0·001）、稳态模型评估指数（P< 0·001）、HDL-c（P< 0·05;相反）和高血压药物（P< 0·05）与IR的发生显著相关。调整混杂因素后，在最高（≥ 0.30 ng/ml）和最低（<0.15 ng/ml）的HGF组中观察到IR发生的显著（P<0.05）相对危险度[1.75（95%CI：1.01 - 3.12）]。结论我们10年的前瞻性研究表明，血清HGF水平升高与IR的发生显著相关。
ObjectiveHepatocyte growth factor (HGF) receptors form a hybrid complex with insulin receptors in the liver of mice, which lead to robust signalling to regulate glucose metabolism. Serum HGF levels are high in subjects with metabolic syndrome and/or obesity. Accordingly, we prospectively investigated the relationship between HGF and the development of insulin resistance (IR) in a general population without IR at baseline.MethodsA total of 1492 subjects received health examinations. After excluding subjects with diabetes and/or IR (n= 402) at baseline, the remaining subjects (n= 1090) were followed‐up 10 years later. Complete data sets were available from 716 subjects for prospective analysis. Logistic regression was performed to determine factors associated with the development of IR after 10 years.ResultsIn subjects without diabetes at baseline, serum HGF levels were higher (0·26 ± 0·10 ng/ml,n= 259) in subjects with IR than without it (0·22 ± 0·09 ng/ml,n= 1090). After deleting subjects who developed liver disease during follow‐up, 188 were found to have developed IR at 10 years after the original screening. HGF (P< 0·05), age (P< 0·001), homoeostasis model assessment index (P< 0·001), HDL‐c (P< 0·05; inversely) and hypertensive medication (P< 0·05) were significantly associated with the development of IR by multivariate stepwise logistic regression analysis. A significant (P< 0·05) relative risk [1·75 (95%CI: 1·01–3·12)] for the development of IR was observed in the highest (≥0·30 ng/ml)vsthe lowest categories (<0·15 ng/ml) of HGF after adjustments for confounders.ConclusionsOur 10‐year prospective study suggests that elevated serum HGF levels were significantly associated with the development of IR.