Postsynaptic membrane fusion and long-term potentiation
Postsynaptic membrane fusion and long-term potentiation
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DOI：
10.1126/science.279.5349.399
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发表时间：
1998-01-16
期刊：
影响因子：
56.9
通讯作者：
Nicoll, RA
中科院分区：
文献类型：
--
作者：
Lledo, PM;Zhang, XY;Nicoll, RA
研究了长时程增强(LTP)引起突触强度改变可能需要突触后细胞膜融合事件的可能性。在突触后细胞中引入一些物质，以不同的步骤阻止膜融合，降低了LTP。将SNAP，一种促进膜融合的蛋白质引入细胞，增强了突触传递，当这种增强在表达LTP的突触中产生时，这种增强明显较小。因此，突触后融合事件，可能参与逆行信号或调节突触后受体功能，或两者兼而有之，参与LTP。
The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP. Introducing SNAP, a protein that promotes membrane fusion, into cells enhanced synaptic transmission, and this enhancement was significantly less when generated in synapses that expressed LTP. Thus, postsynaptic fusion events, which could be involved either in retrograde signaling or in regulating postsynaptic receptor function or both, contribute to LTP.