Microdistribution of 239Pu in the beagle skeleton.
Microdistribution of 239Pu in the beagle skeleton.
复制标题
比格犬骨骼中 239Pu 的微分布。
DOI：
10.1097/00004032-199809000-00003
复制
发表时间：
1998
期刊：
影响因子：
2.2
通讯作者：
Miller,SC
中科院分区：
文献类型：
--
作者：
Polig,E;Bruenger,FW;Lloyd,RD;Miller,SC
采用中子诱导放射自显像技术分析了239 - Pu在年轻成年小猎犬肱骨、腰椎和尺骨近端的微分布。在单次注射3.5 kBq kg体重后，分别于4、8、16、32和64周分3组处死。表面浓度的动力学行为是用一个简单的概念沉积和清除骨骼区域。高周转率的骨骼比低周转率的骨骼表现出更大的初始吸收和更快的清除。使用回归程序，计算了钚的表面沉积和清除作为周转率的函数。随着注射后时间的延长，小梁表面标记的初始不均匀性逐渐趋于均匀。小梁与皮质的亲和比约为10。小梁活动逐渐转移到皮质部位。成形与静止表面的亲和比约为3。在一些骨骼中观察到骨髓星的持续增加，而在其他骨骼中则没有明显的趋势。最高水平的骨髓标记发生在腰椎和肱骨干。
The microdistribution Of 239 Pu was analyzed in the humerus, lumbar vertebra, and proximal ulna of young adult beagles using neutron induced autoradiography. The animals were sacrificed serially in groups of three at 4, 8, 16, 32, and 64 wk after a single injection of 3.5 kBq kg-'body weight. The kinetic behavior of surface concentrations was modeled using a simple concept of deposition and clearance in skeletal regions. Bones with high turnover showed a larger initial uptake and a faster clearance than bones with low turnover rates. Using a regression procedure, the surface deposition and clearance of plutonium was calculated as a function of the turnover rate. With time after injection the initial nonuniformity of trabecular surface labels tends to become more uniform. The trabecular: cortical affinity ratio is about 10. Trabecular activity is gradually translocated to cortical sites. The affinity ratio of forming to resting surfaces is about three. In some bones a continuous increase of marrow stars was observed, whereas in other bones no clear-cut tendency could be seen. The highest level of marrow labeling occurred in the lumbar vertebra and the humerus shaft.