Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia.
Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia.
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DOI：
10.1016/j.tins.2011.05.005
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发表时间：
2011-08
影响因子：
15.9
通讯作者：
Hampel H
中科院分区：
文献类型：
--
作者：
Ewers M;Sperling RA;Klunk WE;Weiner MW;Hampel H
阿尔茨海默病（AD）是一种与年龄相关的进行性神经退行性疾病。在出现痴呆的临床表现时，已经存在严重的不可逆脑损伤，这使得在疾病早期诊断AD成为进行治疗以阻止或至少减缓疾病进展的紧迫前提条件。在这篇综述中，我们讨论了各种神经影像学方法，这些方法被证明在痴呆发病前检测和预测AD方面具有作为AD病理学标志物的潜在价值。我们还讨论了近期一些研究，这些研究在认知处于正常范围的老年人或有轻度认知障碍（MCI）的人群中发现了类似AD的大脑结构和功能变化。文中提出了在不同疾病阶段神经影像学标志物变化的动态序列模型，并考虑了多模态神经影像学对AD痴呆的预测价值。
Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease. At the time of clinical manifestation of dementia, significant irreversible brain damage is already present, rendering the diagnosis of AD at early stages of the disease an urgent prerequisite for therapeutic treatment to halt, or at least slow, disease progression. In this Review, we discuss various neuroimaging measures that are proving to have potential value as biomarkers of AD pathology for the detection and prediction of AD before the onset of dementia. Recent studies that have identified AD-like structural and functional brain changes in elderly people who are cognitively within the normal range or who have mild cognitive impairment (MCI) are discussed. A dynamic sequence model of changes that occur in neuroimaging markers during the different disease stages is presented and the predictive value of multimodal neuroimaging for AD dementia is considered.