Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975
Bioactive compounds from the seed fungus Menisporopsis theobromae BCC 3975
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DOI：
10.1021/np0601197
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发表时间：
2006-10-27
影响因子：
5.1
通讯作者：
Thebtaranonth, Yodhathai
中科院分区：
文献类型：
--
作者：
Chinworrungsee, Maneekarn;Kittakoop, Prasat;Thebtaranonth, Yodhathai
从种子真菌 Menisporopsis theobromae BCC 3975 中分离出八种新化合物 (2-9) 以及已知的二硫二酮哌嗪 (1)。通过光谱数据分析阐明了这些物质的结构。化合物1和4对BC-1细胞系表现出中等的细胞毒性，IC50值分别为29.2和57.4μM。 1、2、4和9针对NCI-H187细胞系的细胞毒性分别显示出22.9、20.3、1.8和56.6μM的IC50值。化合物2和4显示出抗疟活性，IC50值分别为2.95和28.8μM。物质1、4、7、8和9具有弱的抗分枝杆菌活性(MIC 154.8-952.3 μM)，而化合物2和3显示出强的抗分枝杆菌活性，其MIC值分别为1.24和7.14 μM。
Eight new compounds (2-9), together with a known dithiodiketopiperazine ( 1), were isolated from the seed fungus Menisporopsis theobromae BCC 3975. The structures of these substances were elucidated by analyses of spectroscopic data. Compounds 1 and 4 exhibited moderate cytotoxicity against BC-1 cell lines with IC50 values of 29.2 and 57.4 mu M, respectively. Cytotoxicity of 1, 2, 4, and 9 against the NCI-H187 cell line showed respective IC50 values of 22.9, 20.3, 1.8, and 56.6 mu M. Compounds 2 and 4 exhibited antimalarial activity with IC50 values of 2.95 and 28.8 mu M, respectively. Substances 1, 4, 7, 8, and 9 possessed weak antimycobacterial activity ( MIC 154.8-952.3 mu M), while compounds 2 and 3 showed potent antimycobacterial activity with respective MIC values of 1.24 and 7.14 mu M.