Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species
Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species
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DOI：
10.1371/journal.pone.0017775
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发表时间：
2011-03-15
期刊：
影响因子：
3.7
通讯作者：
Horii, Toshihiro
中科院分区：
文献类型：
--
作者：
Arisue, Nobuko;Kawai, Satoru;Horii, Toshihiro
新测定了11种灵长类疟原虫的血清基因序列，其中包括两种人类寄生虫卵形疟原虫和疟疾原虫，并与7个已知种一起分析了血清基因的进化历史。它们都在串联簇中分别具有I到III组半胱氨酸型血清基因和不同数量的IV组丝氨酸型血清基因。值得注意的是，在所有哺乳动物寄生虫谱系中都确定了IV组血清基因；在两个灵长类寄生虫谱系中，复制、截断、片段化和基因丢失等基因事件以模拟出生和死亡进化模型的方式高频发生。在不同的啮齿动物和猴子寄生虫中，个体血清基因的转录谱有很大差异。结果支持疟原虫血清基因家族的谱系特异性进化。这些发现为进一步的研究提供了动力，这些研究可以澄清/提供概念证明，即血清基因的重复与寄生虫宿主范围的扩大和疟原虫多基因家族的进化难题有关。
SERA gene sequences were newly determined from 11 primate Plasmodium species including two human parasites, P. ovale and P. malariae, and the evolutionary history of SERA genes was analyzed together with 7 known species. All have one each of Group I to III cysteine-type SERA genes and varying number of Group IV serine-type SERA genes in tandem cluster. Notably, Group IV SERA genes were ascertained in all mammalian parasite lineages; and in two primate parasite lineages gene events such as duplication, truncation, fragmentation and gene loss occurred at high frequency in a manner that mimics the birth-and-death evolution model. Transcription profile of individual SERA genes varied greatly among rodent and monkey parasites. Results support the lineage-specific evolution of the Plasmodium SERA gene family. These findings provide further impetus for studies that could clarify/provide proof-of-concept that duplications of SERA genes were associated with the parasites' expansion of host range and the evolutionary conundrums of multigene families in Plasmodium.