Integrated [18F]FDG PET/MRI demonstrates the iron-related bone-marrow physiology.
Integrated [18F]FDG PET/MRI demonstrates the iron-related bone-marrow physiology.
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综合 [18F]FDG PET/MRI 展示了与铁相关的骨髓生理学。
DOI：
10.1038/s41598-020-70854-w
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发表时间：
2020
影响因子：
4.6
通讯作者：
Okazawa H.
中科院分区：
文献类型：
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作者：
Tsujikawa T;Oikawa H;Tasaki T;Hosono N;Tsuyoshi H;Rahman MGM;Yoshida Y;Yamauchi T;Kimura H;Okazawa H.
我们在全血细胞计数、c -反应蛋白（CRP）和人体测量因子中确定了骨髓[18F]FDG摄取和MR信号的预测因子，并使用集成[18F]FDG- pet /MRI证明了骨髓生理学。174例无骨髓病变的肿瘤患者行全身FDG-PET/MRI检查[18F]。测量腰椎（L3-5）和双侧髂骨的标准化摄取值（SUV）、表观扩散系数（ADC）、质子密度脂肪分数（PDFF）和T2*弛豫时间倒数（R2*）。椎骨、骨盆和肋骨通过DWI 3点视觉评分进行评估。研究了PET/MR特征与预测因子的关系。多元回归分析发现，CRP是腰椎和髂骨suv的最强预测因子（标准化系数：β = 0.31和β = 0.38），腰椎和髂骨R2* （β = 0.31和β = 0.46）。相反，年龄是影响腰椎和髂骨adc （β = 0.23和β = 0.21）以及腰椎和髂骨pdff （β = 0.53和β = 0.54）的最强因素。在dwi -视觉评分中，年龄是椎骨的最强预测因子（β = - 0.47），红细胞分布宽度（RDW）是骨盆和肋骨的最强预测因子（β = 0.33和β = 0.47）。骨髓[18F]FDG摄取和R2*反映炎症性贫血（颗粒生成增加和铁代谢减少），而骨髓DWI和PDFF反映年龄和贫血性红细胞生成。
We identified predictors for bone-marrow [18F]FDG uptake and MR signals among complete blood count, C-reactive protein (CRP), and anthropometric factors, and demonstrated the bone-marrow physiology using integrated [18F]FDG-PET/MRI. 174 oncology patients without bone-marrow lesions underwent whole-body [18F]FDG-PET/MRI. The standardized uptake value (SUV), apparent diffusion coefficient (ADC), proton density fat-fraction (PDFF), and a reciprocal of T2* relaxation time (R2*) were measured in lumbar vertebrae (L3–5) and bilateral ilia. Vertebrae, pelvis, and ribs were evaluated by 3-point visual scoring on DWI. The association of the PET/MR features with the predictors was examined. Multi-regression analyses identified CRP as the strongest predictor for lumbar and iliac SUVs (standardized coefficient: β = 0.31 and β = 0.38, respectively), and for lumbar and iliac R2* (β = 0.31 and β = 0.46, respectively). In contrast, age was the strongest factor influencing lumbar and iliac ADCs (β = 0.23 and β = 0.21, respectively), and lumbar and iliac PDFFs (β = 0.53 and β = 0.54, respectively). Regarding DWI-visual scores, age was the strongest predictor for vertebrae (β = − 0.47), and the red cell distribution width (RDW) was the strongest predictor for pelvis and ribs (β = 0.33 and β = 0.47, respectively). The bone-marrow [18F]FDG uptake and R2* reflect anemia of inflammation (increased granulopoiesis and reduced iron metabolism), whereas bone-marrow DWI and PDFF reflect age and anemia-responsive erythropoiesis.