The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19.
The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19.
复制标题
维生素C的悠久历史：从预防普通感冒到治疗Covid-19的潜在帮助。
DOI：
10.3389/fimmu.2020.574029
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发表时间：
2020
影响因子：
7.3
通讯作者：
D'Antona G
中科院分区：
文献类型：
--
作者：
Cerullo G;Negro M;Parimbelli M;Pecoraro M;Perna S;Liguori G;Rondanelli M;Cena H;D'Antona G
从鲍林的理论到现在，人们对于维生素C的生理作用以及补充维生素C对健康的影响已经有了相当多的了解。尽管众所周知，满足每日维生素 C 摄入量的均衡饮食会对免疫系统产生积极影响并降低感染的易感性，但现有数据并不支持口服维生素 C 补充剂可增强免疫力的理论。目前尚无临床建议支持在营养良好的普通人群中使用大剂量维生素 C 补充剂可显着降低呼吸道感染风险的可能性。仅在受限亚组（例如运动员或军人）和血浆维生素 C 浓度较低的受试者中，补充可能是合理的。此外，对于感染高危人群（即肥胖者、糖尿病患者、老年人等），补充维生素 C 可以调节炎症，对感染的免疫反应具有潜在的积极作用。额外口服维生素 C 对感冒持续时间以及预防或治疗肺炎的影响仍然受到质疑，而根据危重疾病研究，维生素 C 输注最近被假设为治疗 COVID-19 住院患者的方法。在这篇综述中，我们重点关注维生素C对免疫功能的影响，总结了从常见呼吸道疾病的预防和治疗到维生素C在危重疾病中的使用等最相关的研究，旨在阐明其在急性SARS-CoV2感染期间的潜在应用。
From Pauling’s theories to the present, considerable understanding has been acquired of both the physiological role of vitamin C and of the impact of vitamin C supplementation on the health. Although it is well known that a balanced diet which satisfies the daily intake of vitamin C positively affects the immune system and reduces susceptibility to infections, available data do not support the theory that oral vitamin C supplements boost immunity. No current clinical recommendations support the possibility of significantly decreasing the risk of respiratory infections by using high-dose supplements of vitamin C in a well-nourished general population. Only in restricted subgroups (e.g., athletes or the military) and in subjects with a low plasma vitamin C concentration a supplementation may be justified. Furthermore, in categories at high risk of infection (i.e., the obese, diabetics, the elderly, etc.), a vitamin C supplementation can modulate inflammation, with potential positive effects on immune response to infections. The impact of an extra oral intake of vitamin C on the duration of a cold and the prevention or treatment of pneumonia is still questioned, while, based on critical illness studies, vitamin C infusion has recently been hypothesized as a treatment for COVID-19 hospitalized patients. In this review, we focused on the effects of vitamin C on immune function, summarizing the most relevant studies from the prevention and treatment of common respiratory diseases to the use of vitamin C in critical illness conditions, with the aim of clarifying its potential application during an acute SARS-CoV2 infection.