Antidepressant therapy and C-reactive protein levels
Antidepressant therapy and C-reactive protein levels
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DOI：
10.1192/bjp.bp.105.011015
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发表时间：
2006-05-01
影响因子：
10.5
通讯作者：
Dinan, Timothy G.
中科院分区：
文献类型：
--
作者：
O'Brien, Sinead M.;Scott, Lucinda V.;Dinan, Timothy G.
研究背景抑郁症与炎症反应的激活有关，目的检测抑郁症患者的C反应蛋白水平，并确定选择性5-羟色胺再摄取抑制剂（SSRI）治疗的影响。方法两部分研究在研究1中，采用受试者间设计，检测了32例抑郁症患者的C反应蛋白水平。（20名目前抑郁，12名情绪正常），所有患者均接受SSRI治疗，并在健康对照组（n=20）中。研究2采用了受试者内的设计：C-反应蛋白测定20例抑郁症患者之前和之后SSRI treatment.Results在研究1中，C-反应蛋白水平没有显着差异组与抑郁症（无论是目前抑郁或euthymic）治疗SSRIs和健康组。在研究2中的蛋白质水平显着下降，抗抑郁药物治疗后，SSRI治疗抑郁症有一个显着的下降，C-反应蛋白浓度是否抑郁症解决。这些发现表明，抗抑郁药诱导抗炎反应独立于抗抑郁作用。曾在所有销售品牌SSRI的公司赞助的会议上演讲或担任顾问。
Background Major depression is associated with activation of the inflammatory response.Aims To examine C-reactive protein levels in depression and to determine the impact of selective serotonin reuptake inhibitor (SSRI) therapy.Method A two-part study In study 1, which used a between -subjects design, C-reactive protein was measured in 32 patients (20 currently depressed, 12 euthymic) with a history of DSM - IV major depression, all of whom were treated with an SSRI, and in a healthy comparison group (n=20). Study 2 employed a within-subject design: C-reactive protein was measured in 20 patients with major depression both before and after SSRI treatment.Results In study 1, C- reactive protein levels did not differ between the group with depressive disorder (either currently depressed or euthymic) treated with SSRIs and the healthy group. In study 2 the protein levels dropped significantly following treatment with antidepressant medication.Conclusions Following SSRI treatment for major depression there is a significant drop in C-reactive protein concentrations whether or not the depression resolves. These findings indicate that antidepressants induce an anti -inflammatory response independent of antidepressant action.Declaration of interest T.G.D. has lectured at meetings sponsored by or acted as an advisor to all companies who market a branded SSRI.