Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.
Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.
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细菌脂多糖的结构与其有丝分裂和佐剂功能的关系。
DOI：
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发表时间：
1973
影响因子：
11.1
通讯作者：
W. Weigle
中科院分区：
文献类型：
--
作者：
J. Chiller;B. Skidmore;D. Morrison;W. Weigle
细菌脂多糖诱导淋巴细胞有丝分裂和作为抗体形成的辅助剂的能力可归因于分子的脂质- a区。通过诱导DNA合成测定，脂质A对先天性胸腺疾病小鼠脾脏骨髓源淋巴细胞有丝分裂作用，而对正常小鼠胸腺细胞无丝分裂作用。通过脂质A将抗原耐受方案转化为引起免疫反应的方案，并通过其显著增强对弱抗原的抗体反应的能力，证明了佐剂性。
The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.