Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine
Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine
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DOI：
10.1007/5584_2018_215
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Mozafari, Masoud
中科院分区：
文献类型：
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作者：
Rahmati, Maryam;Pennisi, Cristian Pablo;Mozafari, Masoud
基于干细胞的疗法，利用干细胞再生受损或患病组织的能力，正在广泛考虑用于再生医学应用。然而，关于差的细胞持久性和细胞移植后的植入的限制仍然存在。近年来，研究了几种类型的生物材料来控制移植干细胞的命运，旨在提高其治疗效率。在本章中，我们集中在这些生物材料，其中包括聚合物，陶瓷和纳米生物材料的一般性能。在本章的第一部分，简要解释了干细胞生物学，来源及其微环境。本章的第二部分介绍了一些最新的研究调查不同类型的生物材料和方法，旨在模拟干细胞微环境，更精确地控制干细胞的命运。
Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.