Sonodynamic therapy
Sonodynamic therapy
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DOI：
10.1016/j.ultras.2008.02.003
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发表时间：
2008-08-01
期刊：
影响因子：
4.2
通讯作者：
Ikeda-Dantsuji, Yurika
中科院分区：
文献类型：
--
作者：
Tachibana, Katsuro;Feril, Loreto B., Jr.;Ikeda-Dantsuji, Yurika
近年来，应用非热超声能量联合药物治疗多种疾病的报道较多。此外，微泡和纳米泡作为药物载体/增强剂的引入为超声治疗增加了一个全新的维度。所见效应的非热机制包括由于空化、声流、微射流和辐射力而产生的各种形式的能量，这增加了药物靶向组织、增强药物有效性甚至化学激活某些材料的可能性。例如通过超声增强溶栓剂已被证明对急性中风患者和外周动脉闭塞患者有益。非侵入性低强度聚焦超声与抗癌药物相结合可能有助于缩小肿瘤大小并减少复发，同时减少严重的药物副作用。通过超声能量化学激活药物来治疗动脉粥样硬化和肿瘤是最近被称为“声动力疗法”的另一个新领域。最后，分子成像的进步引起了人们对同时应用超声进行诊断和治疗的巨大期望。针对分子水平的微泡或纳米泡将使医生能够利用超声成像对疾病做出最终诊断，然后立即进行超声治疗。 (C) 2008 Elsevier B.V. 保留所有权利。
Recently, there have been numerous reports on the application of non-thermal ultrasound energy for treating various diseases in combination with drugs. Furthermore, the introduction of microbubbles and nanobubbles as carriers/enhancers of drugs has added a whole new dimension to therapeutic ultrasound. Non-thermal mechanisms for effects seen include various forms of energy due to cavitation, acoustic streaming, micro jets and radiation force which increases possibilities for targeting tissue with drugs, enhancing drug effectiveness or even chemically activating certain materials. Examples such as enhancement of thrombolytic agents by ultrasound have proven to be beneficial for acute stroke patients and peripheral arterial occlusions. Non-invasive low intensity focused ultrasound in conjunction with anti-cancer drugs may help to reduce tumor size and lessen recurrence while reducing severe drug side effects. Chemical activation of drugs by ultrasound energy for treatment of atherosclerosis and tumors is another new field recently termed as "Sonodynamic therapy". Lastly, advances in molecular imaging have aroused great expectations in applying ultrasound for both diagnosis and therapy simultaneously. Microbubbles or nanobubbles targeted at the molecular level will allow medical doctors to make a final diagnosis of a disease using ultrasound imaging and then immediately proceed to a therapeutic ultrasound treatment. (C) 2008 Elsevier B.V. All rights reserved.