Static and dynamic network properties of the repetitive transcranial magnetic stimulation target predict changes in emotion regulation in obsessive-compulsive disorder
Static and dynamic network properties of the repetitive transcranial magnetic stimulation target predict changes in emotion regulation in obsessive-compulsive disorder
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DOI：
10.1016/j.brs.2019.10.017
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发表时间：
2020-03-01
影响因子：
7.7
通讯作者：
Vriend, Chris
中科院分区：
文献类型：
--
作者：
Douw, Linda;Quaak, Mirjam;Vriend, Chris
背景：重复经颅磁刺激（rTMS）是一种非侵入性神经调节技术，用于治疗精神疾病，如强迫症（OCD）。然而，受试者的rTMS反应各不相同。目的/假设：我们假设rTMS目标的基线网络特性可能有助于理解这种变化并预测反应。方法：对19例未服药的强迫症患者应用兴奋性前额叶皮层（dlPFC） rTMS，对17例健康对照应用抑制性dlPFC-rTMS。顶点作为主动控制靶点（19例患者，18例对照组）。rTMS反应被操作为情绪调节任务中个体状态窘迫等级的变化。在基线时，受试者接受静息状态功能MRI检查。通过计算脑网络图谱中各区域活动的小波相干性来构建脑网络。计算了目标的局部和综合静态连通性以及动态网络角色。基线目标区域网络特征与rTMS反应无参数相关。结果：在dipfc刺激的患者中，基线时更大的局部连通性（Kendall's Tau = -0.415, p = 0.013）和更少的混杂作用（Kendall's Tau = 0.389, p = 0.025）与兴奋性rTMS后更大的痛苦减轻有关。在健康受试者和积极对照刺激的患者中没有显著的相关性。结论：治疗前网络拓扑指标预测rtms诱导的强迫症情绪反应变化，基线静息状态局部连通性越高，目标区域时间整合越少，表明刺激效果越强。这些结果可能会导致强迫症的个性化神经调节。(C) 2019作者。Elsevier Inc.出版。
Background: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique to treat psychiatric disorders, such as obsessive-compulsive disorder (OCD). However, the rTMS response varies across subjects.Objective/hypothesis: We hypothesize that baseline network properties of the rTMS target may help understand this variation and predict response.Methods: Excitatory rTMS to the dorsolateral prefrontal cortex (dlPFC) was applied in 19 unmedicated OCD patients, while inhibitory dlPFC-rTMS was applied in 17 healthy controls. The vertex was used as an active control target (19 patients, 18 controls). The rTMS response was operationalized as the individual change in state distress rating during an emotion regulation task. At baseline, subjects underwent resting-state functional MRI. The brain network was constructed by calculating wavelet coherence between regional activity of regions in the Brainnetome atlas. Local and integrative static connectivity and the dynamic network role of the target were calculated. Baseline target region network features were non-parametrically correlated to rTMS response.Results: In the dIPFC-stimulated patients, greater local connectivity (Kendall's Tau = -0.415, p = 0.013) and less promiscuous role of the target (Kendall's Tau = 0.389, p = 0.025) at baseline were related to greater distress reduction after excitatory rTMS. There were no significant associations in healthy subjects nor in the active control stimulated patients.Conclusions: Pre-treatment network topological indices predict rTMS-induced emotional response changes in OCD, such that greater baseline resting-state local connectivity and less temporal integration of the target region imply greater stimulation effects. These results may lead the way towards personalized neuromodulation in OCD. (C) 2019 The Author(s). Published by Elsevier Inc.