Hepatitis C virus (HCV) infection & risk factors for HCV positivity in injecting & non-injecting drug users attending a de-addiction centre in northern India.
Hepatitis C virus (HCV) infection & risk factors for HCV positivity in injecting & non-injecting drug users attending a de-addiction centre in northern India.
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DOI：
10.4103/0971-5916.166596
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Kumar V
中科院分区：
文献类型：
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作者：
Basu D;Sharma AK;Gupta S;Nebhinani N;Kumar V
注射吸毒是印度丙型肝炎病毒（HCV）感染的主要途径，但也可能存在其他风险因素。本研究旨在确定注射吸毒者（IDUs）与非注射吸毒者（NIDUs）的抗HCV抗体血清阳性率，并研究药物使用者总样本中HCV血清阳性的各种人口统计学，临床，行为和个性因素的风险估计。对注射吸毒者（n = 201）和非注射吸毒者（n = 219）进行了人口统计学、临床和行为信息评估，并对依赖的严重程度、风险行为和个性特征进行了评价。用ELISA法检测抗-HCV抗体，并用重组免疫印迹试验（RIBA）证实。几乎三分之一的注射吸毒者（201人中有64人; 31.8%）抗HCV抗体阳性，而非注射吸毒者中只有7人（3.2%）。多因素分析中与HCV感染密切相关的4个危险因素为共用注射器[Exp（B）75.04; 95%CI 18.28-307.96; P<0.001]、重复使用注射器附件（16.39; 3.51-76.92; P<0.001）、输血（5.88; 1.63-21.23; P=0.007）和IDU状态（3.60; 1.26-10.31; P=0.017）。其他变量不太强烈，但与HCV阳性显着相关的多个性伴侣，阿片类药物依赖，风险行为评分，冲动，和较低的年龄开始使用药物。我们的研究表明，抗-HCV抗体在静脉吸毒者中有较高的检出率。在物质使用者中，HCV阳性与几个临床、行为和个性危险因素显著且独立相关。
Injecting drug use is a major route of hepatitis C virus (HCV) infection in India, but there may be other risk factors also. This study was carried out to determine the seroprevalence of anti-HCV antibody in injecting drug users (IDUs) vs. non-IDUs (NIDUs), and to study the risk estimates for HCV seropositivity in the total sample of substance users with regard to various demographic, clinical, behavioural and personality factors. The IDUs (n = 201) and NIDUs (n = 219) were assessed for demographic, clinical and behavioural information, and were rated on instruments for severity of dependence, risk behaviour and personality profiles. Anti-HCV antibody was tested by ELISA and confirmed by recombinant immunoblot assay (RIBA) test. Almost one-third of the IDUs (64 of 201; 31.8%) were positive for anti-HCV antibody, as opposed to only seven (3.2%) of the NIDUs. The four risk factors strongly associated with HCV positivity in multivariate analysis were sharing syringe [Exp(B) 75.04; 95%CI 18.28-307.96; P<0.001], reuse of injection accessories (16.39; 3.51-76.92; P<0.001), blood transfusion (5.88; 1.63-21.23; P=0.007) and IDU status (3.60; 1.26-10.31; P=0.017). Other variables less strongly but significantly associated with HCV positivity were multiple sex partners, opioid dependence, risk behaviour scores, impulsivity, and lower age of onset of drug use. Our study showed a high seroprevalence of anti-HCV antibody in IDUs. In the substance users, HCV positivity was significantly and independently associated with several clinical, behavioural, and personality risk factors.